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تغییرات غلظت پلاسمایی هورمونهای تیروئیدی در گوسفندان تحت محدودیت انرژی و اثر تزریق وریدی لپتین بر آن | ||
| مجله تحقیقات دامپزشکی (Journal of Veterinary Research) | ||
| مقاله 3، دوره 62، شماره 1، فروردین 1386، صفحه 15-20 اصل مقاله (242.27 K) | ||
| نویسندگان | ||
| ارمین توحیدی1؛ همایون خزعلی2؛ امیر نیاسری3؛ مهدی ژندی4 | ||
| 1گروه علوم دامی، دانشکده علوم زراعی و دامی، دانشگاه تهران، کرج | ||
| 2گروه زیست شناسی، دانشکده علوم پایه، دانشگاه شهید بهشتی تهران | ||
| 3گروه علوم درمانگاهی، دانشکده دامپزشکی دانشگاه تهران | ||
| 4دانش آموخته گروه علوم دامی، دانشکده کشاورزی دانشگاه تربیت مدرس تهران | ||
| چکیده | ||
| The aim of this study was to determine changes in the concentration of leptin and thyroid hormone in energyrestricted ewes and effect of leptin injection on thyroid hormone level. In the first experiment, 28 ewes were assigned to two groups(n=14). Ewes were fed by a ration that provided 60% or 100% of maintenance energy requirements during 71 days. Blood samples were collected and body weight(BW) and body condition score(BCS) were determined. In the second experiment, 6 energy-restricted ewes from the first experiment were selected and assigned to two groups(n=3). Ewes were fed a ration that provided 60% of maintenance energy requirements and injected by 1 or 4 ?g leptin/Kg BW. Blood samples were taken and BW and BCS were determined. In the first experiment, concentrations of leptin, T3 and T4, BW and BCS were decreased in energyrestricted ewes(p<0.01). In the second experiment, concentration of T3, T4 and leptin were increased by leptin injection(p<0.01). The results suggested leptin injection may restore thyroid hormone secretion to normal levels in energy-restricted ewes. | ||
| کلیدواژه‌ها | ||
| لپتین؛ محدودیت انرژی؛ میش؛ هورمونهای تیروئیدی | ||
| عنوان مقاله [English] | ||
| CHANGES IN THE PLASMACONCENTRATIONS OF THYROID HORMONES IN ENERGYRESTRICTED EWES AND THE EFFECT OF INTRAVENOUS INJECTION OFLEPTIN ON THEIR LEVELS | ||
| نویسندگان [English] | ||
| armin towhidi1؛ Homayoon Khazali2؛ Amir Niasari Naslaji3؛ Mahdi Zhandi4 | ||
| چکیده [English] | ||
| The aim of this study was to determine changes in the concentration of leptin and thyroid hormone in energyrestricted ewes and effect of leptin injection on thyroid hormone level. In the first experiment, 28 ewes were assigned to two groups(n=14). Ewes were fed by a ration that provided 60% or 100% of maintenance energy requirements during 71 days. Blood samples were collected and body weight(BW) and body condition score(BCS) were determined. In the second experiment, 6 energy-restricted ewes from the first experiment were selected and assigned to two groups(n=3). Ewes were fed a ration that provided 60% of maintenance energy requirements and injected by 1 or 4 Kg leptin/Kg BW.Blood samples were taken and BW and BCS were determined. In the first experiment, concentrations of leptin, T3 and T4, BW and BCS were decreased in energyrestricted ewes(p<0.01). In the second experiment,concentration of T3, T4 and leptin were increased by leptin injection(p<0.01). The results suggested leptin injection may restore thyroid hormone secretion to normal levels in energy-restricted ewes. | ||
| کلیدواژه‌ها [English] | ||
| energy-restriction, Ewe, leptin, thyroid hormones | ||
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