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An Efficient, Three-Component Synthesis of 3,4-Di Hydropyrimidin-2(1H)-Ones Using LaCl3/ClCH2COOH as Environmentally Benign and Green Catalytic System | ||
Journal of Sciences, Islamic Republic of Iran | ||
مقاله 3، دوره 25، شماره 4، اسفند 2014، صفحه 323-327 اصل مقاله (437.09 K) | ||
نوع مقاله: Original Paper | ||
نویسندگان | ||
B. Pouramiri؛ E. Tavakolinejad Kermany* ؛ H. Khajesamani؛ H. Khabazzadeh | ||
Department of Chemistry,Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman 76169, Islamic Republic of Iran | ||
چکیده | ||
An improved, simple, and facile synthesis of 3,4-dihydropyrimidin-2(1H)-ones by employing three-component, one-pot condensation reaction of β-keto ester, aromatic aldehydes, and urea or N-methylurea using LaCl3/ClCH2COOH as an inexpensive and green chemistry catalyst system under solvent-free conditions described. Compared with the classicalBiginelli reaction conditions, this method has the advantages of good to excellent yields (80-99%) and short reaction time. | ||
کلیدواژهها | ||
Dihydropyrimidinones؛ Lanthanum(III)chloride؛ Solvent –free؛ One-pot condensation | ||
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