پیوندهای مفید
اخبار و اعلانات
آمار
| تعداد نشریات | 158 |
| تعداد شمارهها | 6,230 |
| تعداد مقالات | 67,766 |
| تعداد مشاهده مقاله | 115,218,015 |
| تعداد دریافت فایل اصل مقاله | 89,964,599 |
Comparison between Fluconazole and Terbinafine in the treatment of Tinea corporis and Tinea cruris | ||
| Journal of Mycology Research | ||
| مقاله 6، دوره 2، شماره 2، مهر 2015، صفحه 105-110 اصل مقاله (480.4 K) | ||
| نوع مقاله: Original Articles | ||
| نویسندگان | ||
| Mohammad Javad Yazdanpanah1؛ Ali Akbar Shamsian* 2؛ Masoud Shafiee3؛ Mohammad Reza Hedayati-Moghadam4؛ Kiarash Ghazvini5؛ Elham Moghaddas6 | ||
| 1Cutaneous Leishmaniasis Research Center, Department of Dermatology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, | ||
| 2Departments of Parasitology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, | ||
| 3General Physician, Health center, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 4Research Center for HIV/AIDS, HTLV and Viral Hepatitis, Iranian Academic Center for Education, Culture and Research (ACECR), Mashhad, IR Iran. | ||
| 5Associated Professor of Microbiology, Antimicrobial Resistance Research Center, Department of Microbiology, School of Medicine,Mashhad University of Medical Sciences, Mashhad, Iran. | ||
| 6Parasitology Department, Mashhad University of Medical Sciences, Mashhad, Iran. | ||
| چکیده | ||
| Objectives: This study aimed to compare the therapeutic efficacy of Terbinafine and Fluconazole in terms of mycological cure in the treatment of Tinea corporis and Tinea cruris. Method: In this clinical trial, 30 patients with T. corporis and T .cruris were selected. Patients were divided into two groups by random selection. The first group was treated with Fluconazole 150 mg weekly for four weeks and the second group was administered Terbinafine 250 mg daily for two weeks. The participants were followed up till the end of the treatment and one month after treatment. Results: At the end of the treatment, 64.3% of the subjects in Fluconazole group developed clinical and laboratory responses; while the second group developed 75% clinical and 81.3% laboratory cure. One month later, 64.3% in the Fluconazole group were cured, while in the other group, 87.5% were cured. No patient had any side effect. Conclusion: Although, no significant difference was observed between these two groups of patients in clinical and laboratory aspect, as a result of lower price and easier consumption, it is suggested that Fluconazole is more suitable for treatment of Tinea infections. | ||
| کلیدواژهها | ||
| fluconazole؛ terbinafine؛ Tinea corporis؛ Tinea cruris | ||
| مراجع | ||
|
1. Ansar, A., Farshchian, M., Nazeri, H., Ghiasian, S. A., 2011. Clinico-epidemiological and mycological aspects of Tinea incognito in Iran: A 16-year study. Med Mycol J, 52(1):25-32. 2. Bassiri, S., Khaksari, A. A., 2009. Epidemiological survey of dermatophytosis in Tehran, Iran, from 2000 to 2005. Indian J DermatolVenereolLeprol, 75(2): 142-7. 3. Burns, T., Breathnach, S., Griffiths, C., Cox, N., 2004. Rook’s textbook of dermatology. Blackwell publishing, Massachusetts. 4. Falahati, M., Akhlaghi, L., Lari, A. R., Alaghehbandan, R., 2003. Epidemiology Of dermatophytoses in an area south of Tehran, Iran. Mycopathologia, 156(4):279–87. 5. Friedlander, S.F., 1999. The evolving role of Itraconazole, fluconazole and terbinafine in the treatment of Tinea capitis. Pediatr Infect Dis J, 18 (2):205-10. 6. Habif, T. P., 2005. Clinical dermatology, California, Mosby. 7. Faergemann, J., Mörk, N. J., Haglund, A., Odegård, T. A., 1997. Multicentre (double-blind) comparative study to assess the safety and efficacy of fluconazole and griseofulvin in the treatment of Tinea corporis and Tinea cruris. Br J Dermatol, 136(4): 575-7. 8. Gupta, A. K., Cooper, E. A., 2008. Update in antifungal therapy of dermatophytosis. Mycopathologia, 166(5-6): 353-67. 9. Millikan, L.E., 2001. Role of oral antifungal agents for the treatment of superficial fungal infections in immunocompromised patients. Cutis, 68(1):6-14. 10.Kumar, A., Budania, N., Sharma, P., Singh, M., 2013. A comparative study of mycological efficacy of terbinafine and fluconazole in patients of Tinea corporis. IJBR, 4(11): 7-10. 11.Grover, C., Arora, P., Manchanda, V., 2012. Comparative evaluation of griseofulvin, terbinafine and fluconazole in the treatment of Tinea capitis. Int J Dermatol, 51(4):455-8. 12.Rezvani, S. M., Sefidgar, A. A., Hasanjani-Roushan, M., 2010. Clinical patterns and etiology of dermatophytosis in 200 cases in Babol, North of Iran. Casp J Intern Med, 1: 23-26. 13.Naseri, A., Fata, A., Najafzadeh, M. J., Shokri,H., Sepahvand, A., Abdi, J., Shirkani, Y., Fallahi, S., 2013. Surveillance of Dermatophytosis in Northeast of Iran (Mashhad) and Review of Published Studies. Mycopathologi, 176(3-4): 247-253. 14.Sepahvand, A., Abdi, J., Shirkhani, Y., Fallahi, S. h., Tarrahi, M., Soleimannejad, S., 2009. Dermatophytosis in Western Part of Iran, khorramabad. Asian J BiolSci,2 (3): 58-65. 15.Mahmoudabadi, A. Z., 2005. A study of dermatophytosis in South West of Iran (Ahwaz). Mycopathologia, 160(1):21–4. 16.Gupta, A. K., Adam, P., Dlova, N., Lynde, C. W., Hofstader, S., Morar, N., Aboobaker, J., Summerbell, R. C., 2001. Therapeutic options for the treatment of Tinea capitis caused by Trichophyton species: griseofulvin versus the new oral antifungal agents, terbinafine, itraconazole, and fluconazole. PediatrDermatol, 18(5):433-8. 17.Wolff, K., Goldsmith, L. A., Katz, S. I., Gilchrest, B. A., Paller, A. S., Leffell, D. J., 2008. Fitzpatrick’s dermatology in general medicine. California,Mcgrawhill | ||
|
آمار تعداد مشاهده مقاله: 5,054 تعداد دریافت فایل اصل مقاله: 4,321 |
||