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بررسی نقش پیش‌التهابی رزیستین و پروتئین واکنشگر C (CRP) در بیماران مبتلا به دیابت نوع 2: اثر فعالیت‌های ورزشی هوازی و مقاومتی | ||
| نشریه علوم زیستی ورزشی | ||
| مقاله 8، دوره 7، شماره 3، مهر 1394، صفحه 445-460 اصل مقاله (404.71 K) | ||
| نوع مقاله: مقاله پژوهشی Released under CC BY-NC 4.0 license I Open Access I | ||
| شناسه دیجیتال (DOI): 10.22059/jsb.2015.56259 | ||
| نویسندگان | ||
| اصغر توفیقی1؛ زهرا صمدیان* 2؛ جواد طلوعی آذر3 | ||
| 1دانشیار گروه فیزیولوژی ورزشی، دانشکدۀ تربیت بدنی و علوم ورزشی، دانشگاه ارومیه | ||
| 2دکتری تخصصی، گروه فیزیولوژی ورزشی، دانشکدۀ تربیت بدنی و علوم ورزشی، دانشگاه ارومیه | ||
| 3دکتری تخصصی، گروه فیزیولوژی ورزشی، دانشکدۀ تربیت بدنی و علوم ورزشی، دانشگاه تهران، تهران، ایران | ||
| چکیده | ||
| نقش زیست‌نشانگرهای التهابی بیماری‌های قلبی-عروقی در افراد دیابتی در پی اجرای تمرینات ورزشی نامشخص است، ازاین‌رو هدف پژوهش حاضر، بررسی نقش پیش‌التهابی رزیستین و CRP به‌دنبال اجرای تمرینات هوازی و مقاومتی در بیماران مبتلا به دیابت نوع 2 بود. 40 نفر از زنان مبتلا به دیابت نوع 2، به‌طور تصادفی در گروه‌های تمرین هوازی (14 نفر)، مقاومتی (13 نفر) و کنترل (13 نفر) قرار گرفتند. گروه هوازی (تمرین هوازی را هر جلسه 50 -20 دقیقه، با شدت 70-50 درصد حداکثر ضربان قلب)، گروه مقاومتی (تمرین مقاومتی را در 3 مرحلۀ10 تکراری، با شدت 60-40 درصد یک تکرار بیشینه) سه جلسه در هفته و به مدت دوازده هفته انجام دادند. گروه کنترل طی این مدت بدون تمرین بود. نمونه‌های خونی به‌منظور بررسی متغیرهای مورد مطالعه در مراحل پیش و پس‌آزمون جمع‌آوری شدند. تحلیل آماری نتایج با نرم‌افزار spss صورت گرفت. با توجه به نتایج، رزیستین و CRP در دو گروه تمرینی به‌ترتیب افزایش و کاهش، وزن، BMI، درصد چربی بدن، نسبت دور کمر به باسن تنها در گروه هوازی، مقاومت انسولینی تنها در گروه مقاومتی و مقادیر گلوکز، هموگلوبین گلیکوزیله در هر دو گروه تمرینی کاهش یافتند (05/0P≤). رزیستین تنها با CRP در پس‌آزمون گروه مقاومتی رابطۀ معکوس معناداری داشت (05/0P≤). با توجه یافته‌ها به‌نظر نمی‌رسد رزیستین موجب مقاومت انسولینی و عامل پیشگویی‌کنندة بیماری‌های قلبی- عروقی باشد. | ||
| کلیدواژه‌ها | ||
| بیماری‌های قلبی-عروقی؛ پروتئین واکنشگر C؛ تمرینات ورزشی هوازی و مقاومتی؛ دیابت نوع 2؛ رزیستین | ||
| عنوان مقاله [English] | ||
| Evaluation of the Proinflammtory role of Resistin and Creactive Protein (CRP) in Patients with Type 2 Diabetes: Effect of Aerobic and Resistance Exercise | ||
| نویسندگان [English] | ||
| Asghar Tofighei1؛ Zahra Samadian2؛ Javad Tolouei Azar3 | ||
| 1Associate Professor, Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, Urmia University, Urmia, Iran | ||
| 2PhD Student, Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, Urmia University, Urmia, Iran | ||
| 3PhD Student, Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, University of Tehran, Tehran, Iran | ||
| چکیده [English] | ||
| Risk of premature mortality and cardiovascular disease in people with diabetes are twice that of non-diabetics, but the role of inflammatory biomarkers such as resistin and CRP that used for prediction of these disease is unknown after exercise. So, the aim of the present study was to examine the proinflammatory role of resistin and CRP, after aerobic and resistance exercise in patients with type 2 diabetes. 40 women with type 2 diabetes were selected as available and by purposive sampling and were randomly assigned into 2 experimental groups of aerobic training (n = 14), resistance training (n = 13) and control group (n = 13) groups. Aerobic group accomplished (12 weeks of aerobic training, 3 times a week, for 20-50 minutes at 50-70% of maximum heart rate), the resistance group received (resistance training 3 times a week in 3 sets of 10 repetitions with 40-60% of a repetition maximum). The control group was sedentary during the same period. Blood samples to determine the levels of resistin, CRP, insulin, HbA1c and glucose in pre-and post-tests were collected. Statistical analysis was performed using, Dependent t test, one way Anova, Pearson correlation with spss software (version 21). According to statistical analysis of the results, Resistin and CRP increase and decrease, respectively, in both exercise training groups, anthropometric measurements(weight, BMI, %Body fat and Waist to hip ratio) only decreased in aerobic group, insulin resistance only decreased in resistance group and glycated hemoglobin and glucose decreased in both training groups (p≤0/05). Also there was a significant inverse correlation between resistin and CRP in post-test of resistance group (P≤0/05). Due to changes in resistin and CRP levels after exercise, it dose not seem that resistin causes insulin resistance and be a predictive factor for cardiovascular disease. | ||
| کلیدواژه‌ها [English] | ||
| resistin, C reactive protein (CRP), aerobic and resistance training, type 2 diabetes, cardiovascular disease | ||
| مراجع | ||
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1. Abd E-Kader, Sh. (2011). "Aerobic versus resistance exercise training in modulation of insulin resistance, adipocytokines and inflammatory cytokine levels in obese type 2 diabetic patients" . Journal of Advanced research; Vol.2, PP: 179 –83. 2. Azuma, K., Katsukawa, F., Oguchi, S., Murata, M., Yamazaki, H., Shimada, A., et al. (2003). "Resistin and exercise capacity in obese subjects". Med Sci Sports Exerc; Vol.35, No.5, PP: S 34. 3. Bacchi, E., Negari, C., Zanelin, M., Milanese, C., Faccioli, N., Trombetta, M., et al. (2012). "Metabolic effects of aerobic exercise and resistance training in type 2 diabetic subjects". Diabetes care; Vol.35, No.4, PP: 676-82. 4. Burnett, MS., Devaney, JM., Adenika, RJ., Lindsay, R., Howard, BV. (2006). "Cross-sectional associations of resistin, coronary heart disease, and insulin resistance". J Clin Endocrinol Metab; Vol.91, No.1, PP:64-8. 5. Giannopoulou, I., Fernhall, B., Carhart, R., Weinstock, R., Baynard, T., Figueroa, A., et al. (2005). "Effects of diet and/ or exercise on the adipocytokine and in flammatory cytokine levels of postmenopausal women with type 2 diabetes". Metabolism clinical and Experimental; Vol.54, PP: 866 –75. 6. Gordon, LA., Morrison, EY., McGrowder, DA. (2008). "Effect of exercise therapy on lipid profile and oxidative stress indications in patients with type 2 diabetes". BMC Complement Altern Med; 8, PP:21-29. 7. Gueugnon, C., Mougin, F., Simon-Rigaud, ML., Regnard, J., Negre, V., Dumoulin, G. (2012). " Effects of an in- patient treatment program based on regular exercise and a balanced diet on high molecular weight adiponectin, resistin levels, and insulin resistance in adolescents with severe obesity". Appl physiol Nutr Metab; Vol.37. , No.4, PP:672-679. 8. Hammett, CJ., Prapavessis, H., Baldi, JC., Varo, N., Schoenbeck, U., Ameratunga, R., et al. (2006). "Effects of exercise training on 5 inflammatory markers associated with cardiovascular risk". Am Heart J; Vol.151, No.2, PP:367.e7-367.e16. 9. Harwood, HJ. (2012)." The adipocyte as an endocrine organ in the regulation of metabolic homeostasiss". Neuropharmacology; Vol.63, PP: 57-75. 10. Hoefle, G., Saely, CH., Risch, L., Koch, L., Schmid, F., Rein, P., et al. (2007). "Relationship between the adipose-tissue hormone resistin and coronary artery disease". Clin Chim Acta; Vol.386, No.1-2, PP: 1-6. 11. Hughes, S. (2003). "Novel cardiovascular risk factors". J Cardiovasc Nurs; Vol.18, No.2, PP: 131-8. 12. Jackson, AS., Pollock, ML., Ward, A. (1980). "Generalized equations for predictiny body density of women". Med Sci Sports Exerc; Vol.12, No.3, PP:175- 82. 13. Jones, T., Basilio, J., Brophy, RM., Mccammon, M.R., Hickner, RC. (2009). "Long – term exercise training in over weight adolescents improves plasma Peptide YY and resistin". Obesity; Vol.17, No.6, PP: 1189- 95. 14. Jorge, M., Olireira, V., Resende, N., Paraiso, L.,Calixto, A., Diniz, A., et al. (2011). "The effects of aerobic, resistance and comlined exercise on metabolic control, inflammatory markers, adipocytokines and muscle insulin signaling in patients with type 2 diabetes mellitus". Metabolism clinical and experimental; Vol.60, PP: 1244-52. 15. Kadoglou, N., Perrea, D., Iliadis, F., Angelopoulou, N., Liapis, C., Alevizos, M. (2007). "Exercise reduces resistin and inflammatory cytokines in patients with type 2 diabetes". Diabetes care; Vol.3, No.30, PP: 719-21. 16. Leehey, DJ., Moinuddin, I., Bast, JP., Quveshi, S., Jelinek, CS., Cooper, C., et al. (2009)." Aerobic exercise in obese diabetic patient with chronic kidney diseases; a rondomized and controlled pilot study". Cardiovase Diabetol; Vol.62, No.10, PP: 1186 – 605. 17. Marwic, TH., Hordem, MD., Miller, T., Chyun, DA., Bertoni, AG., Blumenthal, LS., et al. (2009). "Exercise training for type 2 diabetes mellitus: impact on carduvascular risk: a scientific statement from the American heart association". Circulation; Vol.119 , No.25, PP: 3244-62. 18. Matthews, DR., Hosker, JP., Rudenski, AS., Naylor, BA., Turner, RC., et al. (1985). "Homeostasis model assessment: insulin resistance and beta – cell function from fasting plasma glucose and insulin concentrations in man". Diabeto Logia; Vol.28, No.7, PP: 412 –19. 19. Maud PJ., Foster C. (2006). " Physiological assessment of human fitness. 2end editions. Champaign". Human kinetics; PP:119-50. 20. Nayebifar, Sh., Afzalpour, ME., Saghebjoo, M., Hedayati, M., Shirzaee, P. (2012). "The effect. of aerobic and resistance trainings on serum C-ReactiveProtein, lipid profile and body composition in overweight women". Modern Care, Scientific Quarterly of Birjand Nursing and Midwifery Faculty; Vol.8, PP: 186-196. 21. Nikander, R., Sievanen, H., Ojala, K., Oiranen, T., Kelleokumpu- Lehitnen, PL., Saarto, T.)2007). "Effects of a vigorous aerobic regimen on physical performance in breast cancer patients – a randomized controlled pilot trial". Acta oncology; Vol.46, PP:181- 6. 22. Prestes, J., Shiguemoto, G., Botero, J., Frollini, A., Dias, R., Leite, R., et al. (2009). "Effects of resistance training on resistin , leptin, cytokines, and muscle force in elderly post – menopausal women". J Sports Sci; Vol.27, No.14, PP: 1607- 15. 23. Qi, Q., Wang, J., Li, H., Yu, Z., Ye, X., Hu, FB., et al. (2008). "Associations of resistin with inflammatory and fibrinolytic markers, insulin resistance and metabolic syndrom in middle – aged and older chinese". Eur J Endocrinol; Vol.159, No.5, PP: 585- 93. 24. Reid, RD., Tolloch. HE., Sigal, RJ., Kenny, GP.,Fortier, M., MCDonnel, et al. (2010). "Effects of aerobic exercise, resistance exercise or bithron patients – reported health Status and well- being in TZDM mellitus: randomized trial". Diabetologia; Vol.53, PP: 632-40. 25. Robergs, RA., Landwehr, R. )2002). The surprising history of the ‘HR max = 220 – age’ equation. J Exerc Physiol online; Vol. 5, No.2, PP: 1-16. 26. Ryan, AS., Pratley, RE. , Elahi, D., Gold berg, AP. (2000). "Changes in plasma leptin and insulin action with resistive training in postmenopausal women". Int J Obes Rlat Metab Disord; Vol. 21 , No.1, PP: 27-32. 27. Saremi, A. (2011). "Sporting exercise and diabetes mellitus type 2: a review on evidences". Journal of Cell and Tissue; Vol.2, No.3, PP:171-181. 28. Shenoy, S., Arora, E., Jaspal, S. (2009). "Effects of progressive resistance training or aerobic exercise on T2DM in Indian Population". Int J Diabetes Metab; Vol.17, PP: 27-30. 29. Shirinzade, M., Shakerhoseini, R., Hoshyarrad, A. (2009). "Nutrient value and adequacy of consumed meal in patient with type II diabetes". Iranian Journal of Endocrinology and Metabolism; Vol.11, No.1, PP: 25- 32. 30. Sigal, RJ., Kenny, GP., Boule, NG., Wells, GA., Prud.homme, D., Fortier, M., et al. (2007). "Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes". Ann Intern Med; Vol.147, PP: 357-69. 31. Steppan, CM., Brown, EJ., Wright, CM., Bahat, S., Baneriee, RR., Dai, CY., et al. )2001(." A family of tissue – specific resistin – like molesues". Proc Natl Acad Sci U.S.A; Vol.98, No.2, PP: 502-6. 32. Swift, DL., Johannsen, NM., Earnest, CP., Blair, SN., Church, TS. (2012). "The Effect of Exercise Training Modality on C-reactive Protein inType-2 Diabetes". Med Sci Sports Exerc; Vol.44, PP:1028–34. 33. Thomas, S., Reading, J., Shephood, R. (1992)." Revision of the physical activity readiness questionnaire (Par – q)". Canadian J sport Sciences; Vol.17, No.4, PP: 338-45. 34. Utzschneider, K., Carr, D., Tong, J., Wallace, T., Hull, R., Zraika, S., et al. (2005). "Resistin is not associated with insulin sesivity or the metabolic syndrom in humans". Diabetologia; Vol.48, No. 11, PP: 2330 –33. 35. Wang, H., Chen, DY., Cao, J., He, ZY., Zhu, BP., Long, M. (2009)."High serum resistin level may be an indicator of the severty of coronary disease in acute coronary syndrome". Chin Med Sci J; Vol.24, No.3, PP:161-6. 36. Yaturu, S., Daberry, RP., Rains, J., Jain S. (2006). "Resistin and adiponectin levels in subjects with coronary artery disease and type 2 diabetes". Cytokine; Vol.34, No. 3-4, PP:219-23. 37. Zhang, MH., Na, B., Schiller, NB., Whooley, MA. (2010). "Resistin, exercise capacity, and inducible ischemia in patients with stable coronary heart disease: Data from the Heart and Soul study". Atherosclerosis; Vol. 213, No.2 , PP: 604-10. | ||
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