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بررسی نقش پیش‌التهابی رزیستین و پروتئین واکنشگر C (CRP) در بیماران مبتلا به دیابت نوع 2: اثر فعالیت‌های ورزشی هوازی و مقاومتی | ||
| نشریه علوم زیستی ورزشی | ||
| مقاله 8، دوره 7، شماره 3، مهر 1394، صفحه 445-460 اصل مقاله (404.71 K) | ||
| نوع مقاله: مقاله پژوهشی Released under CC BY-NC 4.0 license I Open Access I | ||
| شناسه دیجیتال (DOI): 10.22059/jsb.2015.56259 | ||
| نویسندگان | ||
| اصغر توفیقی1؛ زهرا صمدیان* 2؛ جواد طلوعی آذر3 | ||
| 1دانشیار گروه فیزیولوژی ورزشی، دانشکدۀ تربیت بدنی و علوم ورزشی، دانشگاه ارومیه | ||
| 2دکتری تخصصی، گروه فیزیولوژی ورزشی، دانشکدۀ تربیت بدنی و علوم ورزشی، دانشگاه ارومیه | ||
| 3دکتری تخصصی، گروه فیزیولوژی ورزشی، دانشکدۀ تربیت بدنی و علوم ورزشی، دانشگاه تهران، تهران، ایران | ||
| چکیده | ||
| نقش زیست‌نشانگرهای التهابی بیماری‌های قلبی-عروقی در افراد دیابتی در پی اجرای تمرینات ورزشی نامشخص است، ازاین‌رو هدف پژوهش حاضر، بررسی نقش پیش‌التهابی رزیستین و CRP به‌دنبال اجرای تمرینات هوازی و مقاومتی در بیماران مبتلا به دیابت نوع 2 بود. 40 نفر از زنان مبتلا به دیابت نوع 2، به‌طور تصادفی در گروه‌های تمرین هوازی (14 نفر)، مقاومتی (13 نفر) و کنترل (13 نفر) قرار گرفتند. گروه هوازی (تمرین هوازی را هر جلسه 50 -20 دقیقه، با شدت 70-50 درصد حداکثر ضربان قلب)، گروه مقاومتی (تمرین مقاومتی را در 3 مرحلۀ10 تکراری، با شدت 60-40 درصد یک تکرار بیشینه) سه جلسه در هفته و به مدت دوازده هفته انجام دادند. گروه کنترل طی این مدت بدون تمرین بود. نمونه‌های خونی به‌منظور بررسی متغیرهای مورد مطالعه در مراحل پیش و پس‌آزمون جمع‌آوری شدند. تحلیل آماری نتایج با نرم‌افزار spss صورت گرفت. با توجه به نتایج، رزیستین و CRP در دو گروه تمرینی به‌ترتیب افزایش و کاهش، وزن، BMI، درصد چربی بدن، نسبت دور کمر به باسن تنها در گروه هوازی، مقاومت انسولینی تنها در گروه مقاومتی و مقادیر گلوکز، هموگلوبین گلیکوزیله در هر دو گروه تمرینی کاهش یافتند (05/0P≤). رزیستین تنها با CRP در پس‌آزمون گروه مقاومتی رابطۀ معکوس معناداری داشت (05/0P≤). با توجه یافته‌ها به‌نظر نمی‌رسد رزیستین موجب مقاومت انسولینی و عامل پیشگویی‌کنندة بیماری‌های قلبی- عروقی باشد. | ||
| کلیدواژه‌ها | ||
| بیماری‌های قلبی-عروقی؛ پروتئین واکنشگر C؛ تمرینات ورزشی هوازی و مقاومتی؛ دیابت نوع 2؛ رزیستین | ||
| عنوان مقاله [English] | ||
| Evaluation of the Proinflammtory role of Resistin and Creactive Protein (CRP) in Patients with Type 2 Diabetes: Effect of Aerobic and Resistance Exercise | ||
| نویسندگان [English] | ||
| Asghar Tofighei1؛ Zahra Samadian2؛ Javad Tolouei Azar3 | ||
| 1Associate Professor, Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, Urmia University, Urmia, Iran | ||
| 2PhD Student, Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, Urmia University, Urmia, Iran | ||
| 3PhD Student, Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, University of Tehran, Tehran, Iran | ||
| چکیده [English] | ||
| Risk of premature mortality and cardiovascular disease in people with diabetes are twice that of non-diabetics, but the role of inflammatory biomarkers such as resistin and CRP that used for prediction of these disease is unknown after exercise. So, the aim of the present study was to examine the proinflammatory role of resistin and CRP, after aerobic and resistance exercise in patients with type 2 diabetes. 40 women with type 2 diabetes were selected as available and by purposive sampling and were randomly assigned into 2 experimental groups of aerobic training (n = 14), resistance training (n = 13) and control group (n = 13) groups. Aerobic group accomplished (12 weeks of aerobic training, 3 times a week, for 20-50 minutes at 50-70% of maximum heart rate), the resistance group received (resistance training 3 times a week in 3 sets of 10 repetitions with 40-60% of a repetition maximum). The control group was sedentary during the same period. Blood samples to determine the levels of resistin, CRP, insulin, HbA1c and glucose in pre-and post-tests were collected. Statistical analysis was performed using, Dependent t test, one way Anova, Pearson correlation with spss software (version 21). According to statistical analysis of the results, Resistin and CRP increase and decrease, respectively, in both exercise training groups, anthropometric measurements(weight, BMI, %Body fat and Waist to hip ratio) only decreased in aerobic group, insulin resistance only decreased in resistance group and glycated hemoglobin and glucose decreased in both training groups (p≤0/05). Also there was a significant inverse correlation between resistin and CRP in post-test of resistance group (P≤0/05). Due to changes in resistin and CRP levels after exercise, it dose not seem that resistin causes insulin resistance and be a predictive factor for cardiovascular disease. | ||
| کلیدواژه‌ها [English] | ||
| resistin, C reactive protein (CRP), aerobic and resistance training, type 2 diabetes, cardiovascular disease | ||
| مراجع | ||
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