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تأثیررژیم غذایی پرچرب غیر اشباع و تمرین هوازی بر سطوح سرمی ایزوفرم های منتخب آدیپونکتین، مقاومت به انسولین و نیمرخ لیپیدی در موشهای نر چاق | ||
نشریه علوم زیستی ورزشی | ||
مقاله 9، دوره 10، شماره 1، خرداد 1397، صفحه 103-118 اصل مقاله (575.73 K) | ||
نوع مقاله: مقاله پژوهشی Released under CC BY-NC 4.0 license I Open Access I | ||
شناسه دیجیتال (DOI): 10.22059/jsb.2018.250623.1238 | ||
نویسندگان | ||
پیام سعیدی1؛ حمید محبی* 2؛ فرهاد رحمانی نیا3؛ فهیمه محمد قاسمی4 | ||
1استادیار دانشگاه گیلان، رشت، ایران | ||
2استاد دانشگاه گیلان، رشت، گیلان | ||
3استاد دانشگاه گیلان رشت ، گیلان | ||
4گروه بافت شناسی، دانشگاه علوم پزشکی، دانشگاه گیلان، رشت، ایران | ||
چکیده | ||
هدف از مطالعه حاضر، بررسی تأثیر 10 هفته تمرین هوازی و رژیم غذایی پرچرب غیراشباع بر سطوح سرمی آدیپونکتین در موشهای نر چاق میباشد. نمونهبرداری خونی از 48 سر موش صحرایی نر نژاد ویستار(با میانگین وزن 5±195 گرم و سن 8 هفته) پس از ناشتایی شبانه در هفتههای اول، 18 و 28 صورت گرفت. پس از نمونه-برداری پایه،40 سر موش باقیمانده بطور تصادفی به گروه کنترل(16 سر) و رژیم غذایی پرچرب(24 سر) تقسیم شدند. پس از 18 هفته گروه پرچرب به زیرگروههای ورزشی و رژیم پرچرب تقسیم شد. گروه ورزشی به مدت 10 هفته(5 جلسه در هفته)، تمرین هوازی با شدت معادلVo2max 75-70% انجام داد. غلظتهای سرمی آدیپونکتین تام و HMW و همچنین متغیرهای نیمرخ لیپیدی و شاخصهای گلیسمیک اندازهگیری شدند. نتایج این مطالعه نشان داد که تمرین هوازی تحت رژیم پرچرب در مقایسه با غذای پرچرب موجب افزایش معنیدار سطوح سرمی آدیپونکتین تام گردید(01/0>P). همچنین تمام شاخصهای گلیسمیک، کلسترول تام، LDL-C و تریگلیسیرید در گروه تمرین هوازی در مقایسه با غذای پرچرب کاهش یافت(05/0>P). این مطالعه نشان داد که تمرینات هوازی حتی در زمان مصرف غذای پرچرب غیراشباع میتواند سطوح سرمی آدیپونکتین تام را در موشهای چاق افزایش و همسو با آن موجب بهبود نیمرخ لیپیدی و متابولیکی شود. | ||
کلیدواژهها | ||
آدیپونکتین؛ مقاومت به انسولین؛ تمرین هوازی؛ رژیم پرچرب غیر اشباع؛ نیمرخ لیپیدی | ||
عنوان مقاله [English] | ||
Effect of Unsaturated-High-Fat-Diet and Aerobic Training Program on Serum levels of Adiponectin Isoforms, Insulin Resistance and Lipid Profile in Male obese Rats | ||
نویسندگان [English] | ||
Payam Saidie1؛ Hamid Mohebbi2؛ Farhad Rahmani nia3؛ Fahime Mohammad Ghasemi4 | ||
1. Assistant Professor, Guilan University, Rasht, Iran | ||
2. Professor, Guilan University, Rasht, Iran | ||
3. Professor, Guilan University, Rasht, Iran | ||
4Histology Department, Medical science University, Guilan university, Rasht, Iran | ||
چکیده [English] | ||
The aim of present study was to investigate the effect of 10-week aerobic training and unsaturated-high-fat-diet on adiponectin serum in obese male rats. Blood samples were collected of forty-eight wistar male rats (average weight 195±5g, age 8 weeks) at 1st, 18th and 28th weeks after overnight fasting. After first sampling, remaining 40 rats were randomly divided into control (n=16) and high-fat-diet (39% of energy content from unsaturated-fat) (n=24). High-fat-diet group randomly divided in to exercise training and high-fat-diet subgroups after 18 weeks. Exercise training group ran for 10 weeks (5d/wk) with intensity equivalent to 70 to 75% of vo2max. Serum levels of total and HMW adiponectin as well as lipid profile and glycemic variables were measured. The results of this study indicate that in comparison to unsaturated-high-fat-diet, aerobic training in unsaturated-high-fat-diet induced obese male rats, increased serum concentration of total adiponectin significantly (P> 0/01). Also insulin resistance index and serum concentrations of insulin, glucose, total cholesterol, LDL-C and TG were decreased in aerobic exercise compare to high-fat-diet group (P> 0/05). This study indicates that aerobic training increase serum concentrations of total adiponectin in obese male rats even with simultaneous consumption of unsaturated-high-fat-diet and cause improvement in lipid and metabolic profiles. | ||
کلیدواژهها [English] | ||
Adiponectin, insulin resistance, Aerobic training, Unsaturated-high-fat-diet, lipid profile | ||
مراجع | ||
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