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Jafarzadeh Baghan, A., peeri, M., Azarbayjani, M. (2019). The Effect of 4 Weeks of Voluntary Training on Depression-Like Behavior Induced by Childhood Stress and Oxidative Stress in Rats. , 11(1), 63-81. doi: 10.22059/jsb.2018.238877.1189
Abolfazl Jafarzadeh Baghan; Maghsoud peeri; Mohammad Ali Azarbayjani. "The Effect of 4 Weeks of Voluntary Training on Depression-Like Behavior Induced by Childhood Stress and Oxidative Stress in Rats". , 11, 1, 2019, 63-81. doi: 10.22059/jsb.2018.238877.1189
Jafarzadeh Baghan, A., peeri, M., Azarbayjani, M. (2019). 'The Effect of 4 Weeks of Voluntary Training on Depression-Like Behavior Induced by Childhood Stress and Oxidative Stress in Rats', , 11(1), pp. 63-81. doi: 10.22059/jsb.2018.238877.1189
Jafarzadeh Baghan, A., peeri, M., Azarbayjani, M. The Effect of 4 Weeks of Voluntary Training on Depression-Like Behavior Induced by Childhood Stress and Oxidative Stress in Rats. , 2019; 11(1): 63-81. doi: 10.22059/jsb.2018.238877.1189

The Effect of 4 Weeks of Voluntary Training on Depression-Like Behavior Induced by Childhood Stress and Oxidative Stress in Rats

نشریه علوم زیستی ورزشی
Article 5, Volume 11, Issue 1, June 2019, Pages 63-81    PDF (990.72 K)
Document Type: Research Paper I Open Access I Released under CC BY-NC 4.0 license
DOI: 10.22059/jsb.2018.238877.1189
Authors
Abolfazl Jafarzadeh Baghan1; Maghsoud peeri* 2; Mohammad Ali Azarbayjani2
1PhD Student of Biochemistry and Exercise Metabolism, Faculty of Physical Education and Sport Sciences, Islamic Azad University, Central Tehran Branch, Tehran, Iran
2Professor, Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University,Tehran, Iran
Abstract
The aim of this study was to determine the effect of four weeks of voluntary running on running wheel (RW) in adolescence on depression and its effect on oxidative stress in the cerebellum. For this purpose, 24 male rats were randomly divided into 3 groups: control, separated from mother (MS) and separated from mother and running wheel (MS + RW). MS and MS + RW rats were separated from their mothers from postnatal day (PND) 2 to 14 for 180 min. per day. Then, each 4 rats per cage were kept until the 28th day. MS + RW group had access to the running wheel 24 hours a day from the 28th day. At PND 60, depressive-like behaviors were assessed by Open Field Test (OPT), Sucrose Preference Test (SPT), Forced Swimming Test (FST) and Splash test. Biomarker of oxidative stress including mitochondrial reactive oxygen species (ROS) in the cerebellum tissue was also measured. The results showed that voluntary running significantly neutralized depression-like behaviors induced by the maternal separation stress and reduced oxidative stress. Also, the results showed that voluntary running could be useful as a non-pharmacological treatment for depression.
Keywords
Depression-like behavior; early life stress; oxidative stress; voluntary running
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