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بررسی تأثیر سینامالدهید روی عوارض ناشی از اکسیدروی (ZnO) در آبشش ماهی کپور معمولی (Cyprinus carpio) | ||
| شیلات | ||
| دوره 76، شماره 2، خرداد 1402، صفحه 305-316 اصل مقاله (1.86 M) | ||
| نوع مقاله: مقاله پژوهشی | ||
| شناسه دیجیتال (DOI): 10.22059/jfisheries.2023.353163.1358 | ||
| نویسندگان | ||
| فرزاد حیدردخت1؛ سید محمد حسینی* 2؛ شیلا امیدظهیر3 | ||
| 1دانش‌آموخته دکتری دامپزشکی، دانشگاه آزاد واحد بابل، بابل، ایران | ||
| 2استادیار گروه پاتولوژی، دانشکده دامپزشکی، دانشگاه آزاد واحد بابل، بابل، ایران | ||
| 3استادیار گروه زیست دریا، دانشکده علوم دریایی و محیطی، دانشگاه مازندران، بابلسر، ایران | ||
| چکیده | ||
| امروزه استفاده از گیاهان به‌عنوان یکی از راه های درمانی آلودگی با فلزات سنگین بسیار مورد توجه قرار گرفته است. دارچین از جمله گیاهانی است که دارای خواص درمانی بسیاری است که این خواص به علت مواد مؤثر موجود در آن است. یکی از مهمترین مواد مؤثر دارچین سینامالدهید است. در مطالعة حاضر اثر درمانی سینامالدهید بر ضایعات ناشی از اکسید روی (ZnO) در آبشش ماهی کپور معمولی (Cyprinus carpio) مورد بررسی قرار گرفت. ماهی‌های کپور معمولی در 5 گروه با سه تکرار تقسیم شدند. گروه 1 به‌عنوان شاهد در نظر گرفته شد، گروه 2 در معرض 3 میلی‌گرم در لیتر اکسید روی قرار گرفت و گروه‌های 3، 4 و 5 علاوه بر دریافت اکسید روی به‌ترتیب غلظت‌های 3/6، 7/2 و 10/8 میلی‌گرم سینامالدهید را در 100 گرم غذا به‌صورت خوراکی به‌مدت 45 روز دریافت کردند. سپس از هر گروه 6 ماهی به‌طور تصادفی جدا و از آبشش ماهی‌ها نمونه‌‌برداری شد. در این مطالعه بیشترین میزان غلظت روی، کمترین مقدار فعالیت کل آنتی‌اکسیدانی و بیشترین مقدار شاخص پراکسیداسیون لیپید در گروه 2 مشاهده شد. همچنین شدیدترین آسیب در گروه 2 به‌صورت هیپرپلازی سلول‌های بافت پوششی، اتصال، آتروفی و تخریب تیغه‌های آبششی ثانویه، پرخونی، تلنژکتازی و نفوذ سلول‌های آماسی مشاهده گردید. در گروه‌های درمانی با افزایش میزان دریافت سینامالدهید غلظت روی، علایم آسیب‌شناسی بافت و مقدار شاخص پراکسیداسیون لیپید کاهش و مقدار فعالیت کل آنتی‌اکسیدانی افزایش پیدا کردند. نتایج حاصل از این مطالعه نشان داد سینامالدهید در مقابل عوارض ناشی از اکسید روی تأثیر حفاظتی و درمانی دارد. بیشترین اثر حفاظتی در گروه 5 به‌صورت کاهش تجمع زیستی روی، بهبود علایم آسیب‌شناسی بافتی ناشی از روی، کاهش مقدار شاخص پراکسیداسیون لیپید و افزایش مقدار فعالیت کل آنتی‌اکسیدانی مشاهده گردید. | ||
| کلیدواژه‌ها | ||
| ماهی کپور معمولی؛ دارچین؛ فلزات سنگین؛ تجمع زیستی؛ آنتی‌اکسیدان | ||
| عنوان مقاله [English] | ||
| The effect of cinnamaldehyde on the lesions caused by zinc oxide (ZnO) in the gills of common carp (Cyprinus carpio) | ||
| نویسندگان [English] | ||
| Farzad Heidardokht1؛ Seyed Mohammad Hosseini2؛ Shila Omidzahir3 | ||
| 1Graduated student, Faculty of Veterinary Medicine, Islamic Azad University, Babol branch, Babol, Iran | ||
| 2Assistant Professor, Department of Pathology, Faculty of Veterinary Medicine, Islamic Azad University, Babol branch, Babol, Iran | ||
| 3Assistant Professor, Faculty of Marine and environmental Sciences, University of Mazandaran, Babolsar, Iran | ||
| چکیده [English] | ||
| Nowadays, the use of plants as one of the treatment methods of heavy metal pollution is considered. Cinnamon is one of the plants that has many therapeutic properties due to its effective ingredients. One of the most important effective ingredients of cinnamon is cinnamaldehyde. In the current study, the therapeutic effect of cinnamaldehyde on the lesions caused by zinc oxide (ZnO) in the gills of common carp (Cyprinus carpio) was investigated. In this study, common carp were divided into 5 groups in triplicates. Group 1 was considered as a control, group 2 was exposed to 3mg/L of zinc oxide, and groups 3, 4, and 5, in addition to receiving zinc oxide received concentrations of 3.6, 7.2, and 10.8mg of cinnamaldehyde in 100g diet, respectively for a period of 45 days. Then, 6 fishes were randomly selected from each group and their gills were sampled. The highest amount of zinc concentration, the lowest amount of total antioxidant activity and the highest amount of lipid peroxidation index were observed in group 2. Also, the most severe damage was observed in group 2 including epithelial cells hyperplasia, adhesion, atrophy and destruction of secondary lamellae, hyperemia, telangiectasia and infiltration of inflammatory cells. In the treatment groups with increase of cinnamaldehyde in the diets, zinc concentration, histopathology symptoms and lipid peroxidation index decreased, while the amount of total antioxidant activity increased. The results of this study showed that cinnamaldehyde has a protective and therapeutic effect against the damage caused by zinc oxide. The most protective effect was observed in group 5 including decrease of Zn bioaccumulation, improving histopathology symptoms, reducing the value of lipid peroxidation index and increasing the value of total antioxidant activity. | ||
| کلیدواژه‌ها [English] | ||
| Cyprinus carpio, Cinnamon, Heavy metals, Bioaccumulation and Antioxidant | ||
| مراجع | ||
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Al-taee, S., Al-hamedani, A., 2013. Pathological study of Lethal Concentration of N-ZnO in Common Carp Cyprinus Carpio L. Basrah Journal of Veterinary Research 12(1), 200-207. Al-Weher, SM., 2008. Levels of heavy metal Cd, Cu and Zn in three fish species collected from the Northern Jordan Valley, Jordan. Jordan Journal of Biological Sciences 1(1), 41-46. Amer, S.A., Metwally, A.E., Ahmed, S.A., 2018. The influence of dietary supplementation of cinnamaldehyde and thymol on the growth performance, immunity and antioxidant status of monosex Nile tilapia fingerlings (Oreochromis niloticus). The Egyptian Journal of Aquatic Research 44(3), 251-256. Ataie, Z., Mehrani, H., Ghasemi, A., Farrokhfall, K., 2019. Cinnamaldehyde has beneficial effects against oxidative stress and nitric oxide metabolites in the brain of aged rats fed with long-term, high-fat diet. Journal of Functional Foods 52(1), 545-551. Bancroft, J.D., Gamble, M. eds., 2008. Theory and practice of histological techniques. Elsevier health sciences. pp: 126-127. Benzie, I.F., Strain, J.J., 1996. The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay. Analytical biochemistry 239(1), 70-76. Buege, JA., Aust, SD., 1978. Microsomal lipid peroxidation. In Methods in enzymology 52, 302-310. Chang, S.T., Chen, P.F., Chang, S.C., 2001. Antibacterial activity of leaf essential oils and their constituents from Cinnamomum osmophloeum. Journal of Ethnopharmacology 77(1), 123-127. Chao, L.K., Hua, K.F., Hsu, H.Y., Cheng, S.S., Liu, J.Y., Chang, S.T., 2005. Study on the antiinflammatory activity of essential oil from leaves of Cinnamomum osmophloeum. Journal of Agricultural and Food Chemistry 53(18), 7274-7278. Faikoh, E.N., Hong, Y.H., Hu, S.Y., 2014. Liposome-encapsulated cinnamaldehyde enhances zebrafish (Danio rerio) immunity and survival when challenged with Vibrio vulnificus and Streptococcus agalactiae. Fish & Shellfish Immunology 38(1), 15-24. Fathiazad, F., Khaki, A., Nouri, M., Afshin, K.A., 2013. Effect of Cinnamon Zeylanicum on serum Testosterone and anti-oxidants levels in Rats. International Journal of Women's Health and Reproduction Sciences 1(1), 29-35. Farombi, E.O., Adelowo, O.A., Ajimoko, Y.R., 2007. Biomarkers of oxidative stress and heavy metal levels as indicators of environmental pollution in African cat fish (Clarias gariepinus) from Nigeria Ogun River. International Journal of Environmental Research and Public Health 4(2), pp.158-165. Hansen, BH., Rømma, S., Garmo, ØA., Pedersen, SA., Olsvik, PA., Andersen, RA., 2007. Induction and activity of oxidative stress-related proteins during waterborne Cd/Zn-exposure in brown trout (Salmo trutta). Chemosphere 67(11):2241-9. Hao, L. and Chen, L., 2012. Oxidative stress responses in different organs of carp (Cyprinus carpio) with exposure to ZnO nanoparticles. Ecotoxicology and Environmental Safety 80(6), 103-110. Hilmy, A.M., El Domiaty, N.A., Daabees, A.Y., Alsarha, A., 1987. The toxicity to Clarias lazera of copper and zinc applied jointly. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology 87(2), 309-314. Hosni, A.A., Abdel-Moneim, A.A., Abdel-Reheim, E.S., Mohamed, S.M., Helmy, H., 2017. Cinnamaldehyde potentially attenuates gestational hyperglycemia in rats through modulation of PPARγ, proinflammatory cytokines and oxidative stress. Biomedicine & Pharmacotherapy 88(4), 52-60. Hoseinifard, S.M., Omidzahir, S., Hoseini, S.M., Beikaee, H., 2018. Protective effect of garlic (Allium sativum) against zinc poisoning in the testicular tissue of goldfish (Carassius auratus). Comparative Clinical Pathology 27(2), pp.357-361. Iqbal, S., Jabeen, F., Peng, C., Ijaz, M.U., Chaudhry, A.S., 2020. Cinnamomum cassia ameliorates Ni-NPs-induced liver and kidney damage in male Sprague Dawley rats. Human & Experimental Toxicology 39(11), 1565-1581. Jiang, X., Wang, W., Wang, S., Zhang, B., Hu, J., 2012. Initial identification of heavy metals contamination in Taihu Lake, a eutrophic lake in China. Journal of Environmental Sciences 24(9),1539-1548. Jia, X., Zhang, H., Liu, X., 2011. Low levels of cadmium exposure induce DNA damage and oxidative stress in the liver of Oujiang colored common carp Cyprinus carpio var. color. Fish physiology and Biochemistry 37(1), 97-103. Khodabakhshi, L., Poorbagher, H., Hosseini, SV., 2017. Effects of Different Exposure Time and Concentration of Zinc Oxide (ZnO) Nanoparticles on the Histopathological Changes of the Gill in Rainbow Trout (Oncorhynchus mykiss). Journal of Fisheries. 70(1), 85-94. (In Persian). Limón-Pacheco, J., Gonsebatt, M.E., 2009. The role of antioxidants and antioxidant-related enzymes in protective responses to environmentally induced oxidative stress. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 674(1-2), 137-147. Methew, S., Abraham, T.E., 2006. In vitro antioxidant activity and scavenging effects of Cinnamonum verum leaf extract assayed by different methodological. Food and Chemical Toxicology 44(2), 198-209. Ouyang, P., Chen, J., Yin, L., Geng, Y., Chen, D., Wang, K., Lai, W., Guo, H., Fang, J., Chen, Z., Tang, L., 2021. The sub-inhibitory concentration of cinnamaldehyde resists Aeromonas hydrophila pathogenicity via inhibition of W-pili production. Aquaculture International 29(4), 1639-1655. Pandey, S., Parvez, S., Ansari, R.A., Ali, M., Kaur, M., Hayat, F., Ahmad, F., Raisuddin, S., 2008. Effects of exposure to multiple trace metals on biochemical, histological and ultrastructural features of gills of a freshwater fish, Channa punctata Bloch. Chemico-Biological Interactions 174(3), 183-192. Puspitasari, A.W., Arfiati, D., Hu, S.Y., 2018. Effect of cinnamaldehyde addition on zebrafish (Danio rerio) eggs against Streptococcus agalactiae infection. Research Journal of Life Science 4(3), 190-198. Rajeshkumar, S., Liu, Y., Ma, J., Duan, H.Y., Li, X., 2017. Effects of exposure to multiple heavy metals on biochemical and histopathological alterations in common carp, Cyprinus carpio L. Fish & Shellfish Immunology 70(11), 461-472. Sevcikova, M., Modra, H., Blahova, J., Dobsikova, R., Plhalova, L., Zitka, O., Hynek, D., Kizek, R., Skoric, M., Svobodova, Z., 2016. Biochemical, haematological and oxidative stress responses of common carp (Cyprinus carpio L.) after sub-chronic exposure to copper. Veterinarni Medicina 61(1), 35-50 Sharma, U.K., Sharma, A.K., Pandey, A.K., 2016. Medicinal attributes of major phenylpropanoids present in cinnamon. BMC Complementary and Alternative Medicine 16(1), 1-11. Skidmore, J.F., 1964. Toxicity of zinc compounds to aquatic animals, with special reference to fish. The Quarterly Review of Biology 39(3), 227-248. Subashkumar, S., Selvanayagam, M., 2014. First report on: Acute toxicity and gill histopathology of fresh water fish Cyprinus carpio exposed to Zinc oxide (ZnO) nanoparticles. International Journal of Scientific and Research Publications 4(3), 1-4. Talas, Z.S., Orun, I., Ozdemir, I., Erdogan, K., Alkan, A., Yılmaz, I., 2008. Antioxidative role of selenium against the toxic effect of heavy metals (Cd+ 2, Cr+ 3) on liver of rainbow trout (Oncorhynchus mykiss Walbaum 1792). Fish Physiology and Biochemistry 34(3), 217-222. Thophon, S., Kruatrachue, M., Upatham, E.S., Pokethitiyook, P., Sahaphong, S., Jaritkhuan, S., 2003. Histopathological alterations of white seabass, Lates calcarifer, in acute and subchronic cadmium exposure. Environmental Pollution 121(3), 307-320. Vinodhini, R., Narayanan, M., 2008. Bioaccumulation of heavy metals in organs of fresh water fish Cyprinus carpio (Common carp). International Journal of Environmental Science & Technology 5(2), 179-182. Vutukuru, S.S., 2005. Acute effects of hexavalent chromium on survival, oxygen consumption, hematological parameters and some biochemical profiles of the Indian major carp, Labeo rohita. International Journal of Environmental Research and Public Health 2(3), 456-462. Wang, Y., Wang, Q., Xing, K., Jiang, P., Wang, J., 2021. Dietary cinnamaldehyde and Bacillus subtilis improve growth performance, digestive enzyme activity, and antioxidant capability and shape intestinal microbiota in tongue sole, Cynoglossus semilaevis. Aquaculture 531(2), 735798. Zhou, Y., Jiang, W.D., Zhang, J.X., Feng, L., Wu, P., Liu, Y., Jiang, J., Kuang, S.Y., Tang, L., Peng, Y., Zhou, X.Q., 2020. Cinnamaldehyde improves the growth performance and digestion and absorption capacity in grass carp (Ctenopharyngodon idella). Fish Physiology and Biochemistry 46(4), 1589-1601. | ||
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