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Lapening, Melbagrace, Rivera, Rolen Brian, Unabia, Romnick, Reazo, Renzo Luis, Omping, Jahor, Lumod, Ryan, Ruda, Archie, Ceniza, Amyzz, Sayson, Noel Lito, Latayada, Felmer, Capangpangan, Rey, Dumancas, Gerard, Lubguban, Arnold, Malaluan, Roberto, Hosseini-Bandegharaei, Ahmad, Petalcorin Jr., Gaudencio, Alguno, Arnold. (1403). One-Step Synthesis of PEG-Functionalized Gold Nanoparticles: Impact of Low Precursor Concentrations on Physicochemical Properties. , 57(2), 135-144. doi: 10.22059/jufgnsm.2024.02.04
Melbagrace Lapening; Rolen Brian Rivera; Romnick Unabia; Renzo Luis Reazo; Jahor Omping; Ryan Lumod; Archie Ruda; Amyzz Ceniza; Noel Lito Sayson; Felmer Latayada; Rey Capangpangan; Gerard Dumancas; Arnold Lubguban; Roberto Malaluan; Ahmad Hosseini-Bandegharaei; Gaudencio Petalcorin Jr.; Arnold Alguno. "One-Step Synthesis of PEG-Functionalized Gold Nanoparticles: Impact of Low Precursor Concentrations on Physicochemical Properties". , 57, 2, 1403, 135-144. doi: 10.22059/jufgnsm.2024.02.04
Lapening, Melbagrace, Rivera, Rolen Brian, Unabia, Romnick, Reazo, Renzo Luis, Omping, Jahor, Lumod, Ryan, Ruda, Archie, Ceniza, Amyzz, Sayson, Noel Lito, Latayada, Felmer, Capangpangan, Rey, Dumancas, Gerard, Lubguban, Arnold, Malaluan, Roberto, Hosseini-Bandegharaei, Ahmad, Petalcorin Jr., Gaudencio, Alguno, Arnold. (1403). 'One-Step Synthesis of PEG-Functionalized Gold Nanoparticles: Impact of Low Precursor Concentrations on Physicochemical Properties', , 57(2), pp. 135-144. doi: 10.22059/jufgnsm.2024.02.04
Lapening, Melbagrace, Rivera, Rolen Brian, Unabia, Romnick, Reazo, Renzo Luis, Omping, Jahor, Lumod, Ryan, Ruda, Archie, Ceniza, Amyzz, Sayson, Noel Lito, Latayada, Felmer, Capangpangan, Rey, Dumancas, Gerard, Lubguban, Arnold, Malaluan, Roberto, Hosseini-Bandegharaei, Ahmad, Petalcorin Jr., Gaudencio, Alguno, Arnold. One-Step Synthesis of PEG-Functionalized Gold Nanoparticles: Impact of Low Precursor Concentrations on Physicochemical Properties. , 1403; 57(2): 135-144. doi: 10.22059/jufgnsm.2024.02.04

One-Step Synthesis of PEG-Functionalized Gold Nanoparticles: Impact of Low Precursor Concentrations on Physicochemical Properties

Journal of Ultrafine Grained and Nanostructured Materials
دوره 57، شماره 2، اسفند 2024، صفحه 135-144    اصل مقاله (1.42 M)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22059/jufgnsm.2024.02.04
نویسندگان
Melbagrace Lapening1؛ Rolen Brian Rivera* 1؛ Romnick Unabia2؛ Renzo Luis Reazo1؛ Jahor Omping1؛ Ryan Lumod3؛ Archie Ruda4؛ Amyzz Ceniza5؛ Noel Lito Sayson6؛ Felmer Latayada7؛ Rey Capangpangan8؛ Gerard Dumancas9؛ Arnold Lubguban10؛ Roberto Malaluan10؛ Ahmad Hosseini-Bandegharaei11؛ Gaudencio Petalcorin Jr.12؛ Arnold Alguno13
1Research Center for Energy Efficient Materials (RCEEM), Premier Research Institute of Science and Mathematics (PRISM), Mindanao State University-Iligan Institute of Technology, 9200 Iligan City, Philippines
2IT and Physics Department, College of Natural Sciences and Mathematics, Mindanao State University - General Santos, General Santos City, 9500 South Cotabato, Philippines
3Research Center for Energy Efficient Materials (RCEEM), Premier Research Institute of Science and Mathematics (PRISM), MSU-Iligan Institute of Technology, 9200 Iligan City, Philippines
4Research Center on Energy Efficient Materials (RCEEM), Premier Research Institute in Science and Mathematics (PRISM), Mindanao State University − Iligan Institute of Technology, Iligan City 9200, Philippines
5Department of Physical Sciences and Mathematics, College of Marine and Allied Sciences, Mindanao State University at Naawan, Naawan 9023, Misamis Oriental, Philippines
6Department of Physics, Mindanao State University-Iligan Institute of Technology, 9200 Iligan City, Philippines
7Department of Chemistry, Caraga State University, Butuan City 8600, Philippines
8Mindanao State University at Naawan Campus, Naawan Misamis Oriental 9023, Philippines
9Department of Chemistry, New Science Building, North Carolina Agricultural and Technical State University 1601 E. Market Street, Greensboro, NC 27411 USA
10Center for Sustainable Polymers, MSU-Iligan Institute of Technology, Iligan City 9200, Philippines
11Faculty of Chemistry, Semnan University, Semnan, the Islamic Republic of Iran
12Department of Mathematics and Statistics, Mindanao State University-Iligan Institute of Technology, 9200 Iligan City, Philippines
13Department of Materials and Resources Engineering and Technology, MSU-Iligan Institute of Technology, Iligan City 9200, Philippines
چکیده
Polyethylene glycol-capped gold nanoparticles (PEG-AuNPs) are highly promising for biological and medical applications due to their biocompatibility, enhanced stability, and low cytotoxicity. The successful synthesis method presented here was a one-step process where both reduction and functionalization took place simultaneously using lower concentrations of gold precursors. Unlike previous methods that used higher concentrations (> 10 mM) and did not explore varying molar ratios, this study investigates the physicochemical properties of PEG-AuNPs synthesized with precursor concentrations ranging from 0.5 mM to 5 mM. Transmission electron microscopy images revealed an increase in the particle sizes of spherical nanoparticles from 14.5nm to 46.7nm as the precursor concentration increased, consistent with dynamic light scattering measurements. UV-Vis spectroscopy confirmed that spherical nanoparticles were formed having surface plasmon resonance peaks ranging from 520-530nm. Fourier transform infrared spectroscopy analyses revealed the interactions between PEG ligands and gold nanoparticles where some specific peaks exist around 1632cm⁻¹ while the O-H stretching peak shifted from approximately 3400 cm⁻¹ to about 3490 cm⁻¹, confirming successful surface modification. Photoluminescence spectroscopy revealed maximum emission particularly observed at the lowest precursor concentration (0.5 mM). Importantly, the synthesized PEG-AuNPs even at the lowest precursor concentration of 0.5mM demonstrated exceptional stability in saline conditions, maintaining dispersion even in the presence of 500 mM NaCl. This one-step synthesis method at reduced precursor concentrations not only enables precise control over the nanoparticles' size and optical properties but also enhances their stability and tunable fluorescence. These findings present a scalable and versatile approach for the tailored synthesis of PEG-AuNPs, making them suitable for advanced biological and medical sensing applications.
کلیدواژه‌ها
Gold nanoparticles؛ Precursor concentration؛ One-step synthesis؛ Polyethylene glycol
مراجع
 

  1. Khalid K, Tan X, Mohd Zaid HF, Tao Y, Lye Chew C, Chu DT, et al. Advanced in Developmental Organic and Inorganic Nanomaterial: A Review. Bioengineered. 2020;11(1):328-355.
  2. Tran CD, Prosenc F, Franko M. Facile Synthesis, Structure, Biocompatibility and Antimicrobial Property of Gold Nanoparticle Composites from Cellulose and Keratin. J Colloid Interface Sci. 2018;510:237-245.
  3. Anselmo AC, Mitragotri S. Nanoparticles in the Clinic: An Update. Bioeng Transl Med. 2019;4(3).
  4. Singh P, Pandit S, Mokkapati VRSS, Garg A, Ravikumar V, Mijakovic I. Gold Nanoparticles in Diagnostics and Therapeutics for Human Cancer. Int J Mol Sci. 2018;19(7):1979.
  5. Kong FY, Zhang JW, Li RF, Wang ZX, Wang WJ, Wang W. Unique Roles of Gold Nanoparticles in Drug Delivery, Targeting and Imaging Applications. Molecules. 2017;22(9):1445.
  6. Siddique S, Chow JCL. Gold Nanoparticles for Drug Delivery and Cancer Therapy. Appl Sci. 2020;10(11):3824.
  7. Yang Z, Wang D, Zhang C, Liu H, Hao M, Kan S, et al. The Applications of Gold Nanoparticles in the Diagnosis and Treatment of Gastrointestinal Cancer. Front Oncol. 2022;11:819329.
  8. Turkevich J, Stevenson PC, Hillier J. A Study of the Nucleation and Growth Processes in the Synthesis of Colloidal Gold. Discuss Faraday Soc. 1951;11:55.
  9. Frens G. Controlled Nucleation for the Regulation of the Particle Size in Monodisperse Gold Suspensions. Nat Phys Sci. 1973;241(105):20-22.
  10. Xin Lee K, Shameli K, Miyake M, Kuwano N, Bt Ahmad Khairudin NB, Bt Mohamad SE, et al. Green Synthesis of Gold Nanoparticles Using Aqueous Extract of Garcinia Mangostana Fruit Peels. J Nanomater. 2016;2016:1-7.
  11. Zhang T, Dang M, Zhang W, Lin X. Gold Nanoparticles Synthesized from Euphorbia Fischeriana Root by Green Route Method Alleviates the Isoprenaline Hydrochloride Induced Myocardial Infarction in Rats. J Photochem Photobiol B. 2020;202:111705.
  12. Rajasekar T, Karthika K, Muralitharan G, Maryshamya A, Sabarika S, Anbarasu S, et al. Green Synthesis of Gold Nanoparticles Using Extracellular Metabolites of Fish Gut Microbes and Their Antimicrobial Properties. Braz J Microbiol. 2020;51(3):957-967.
  13. Chowdhury NK, Choudhury R, Gogoi B, Chang CM, Pandey RP. Microbial Synthesis of Gold Nanoparticles and Their Application. Curr Drug Targets. 2022;23(7):752-760.
  14. Javed R, Sajjad A, Naz S, Sajjad H, Ao Q. Significance of Capping Agents of Colloidal Nanoparticles from the Perspective of Drug and Gene Delivery, Bioimaging, and Biosensing: An Insight. Int J Mol Sci. 2022;23(18):10521.
  15. Al-Ghamdi A, Indumathi T, Ranjith Kumar E. Green Synthesized Zinc Oxide Nanoparticles: Effect of Polyethylene Glycol and Chitosan on Structural, Optical and Morphological Analysis. Ceram Int. 2022;48(13):18324-18329.
  16. Javed R, Zia M, Naz S, Aisida SO, Ain NU, Ao Q. Role of Capping Agents in the Application of Nanoparticles in Biomedicine and Environmental Remediation: Recent Trends and Future Prospects. J Nanobiotechnology. 2020;18(1):172.
  17. Rahme K, Dagher N. Chemistry Routes for Copolymer Synthesis Containing PEG for Targeting, Imaging, and Drug Delivery Purposes. Pharmaceutics. 2019;11(7):327.
  18. Carreón González JL, García Casillas PE, Chapa González C. Gold Nanoparticles as Drug Carriers: The Role of Silica and PEG as Surface Coatings in Optimizing Drug Loading. Micromachines. 2023;14(2):451.
  19. 19. Zamora-Justo JA, Abrica-González P, Vázquez-Martínez GR, Muñoz-Diosdado A, Balderas-López JA, Ibáñez-Hernández M. Polyethylene Glycol-Coated Gold Nanoparticles as DNA and Atorvastatin Delivery Systems and Cytotoxicity Evaluation. J Nanomater. 2019;2019:1-11.
  20. Manson J, Kumar D, Meenan BJ, Dixon D. Polyethylene glycol functionalized gold nanoparticles: the influence of capping density on stability in various media. Gold Bull. 2011;44:99–105.
  21. López-Marzo AM, Hoyos-de-la-Torre R, Baldrich E. NaNO3/NaCl Oxidant and Polyethylene Glycol (PEG) Capped Gold Nanoparticles (AuNPs) as a Novel Green Route for AuNPs Detection in Electrochemical Biosensors. Anal Chem. 2018;90(6):4010-4018.
  22. Özçiçek İ, Çakici Ç, Ayşit N, Erim ÜC. The Effects of Gold Nanoparticles with Different Surface Coatings and Sizes on Biochemical Parameters in Mice. Eur Res J. 2023;9(1):131-139.
  23. Leopold N, Chiş V, Mircescu NE, Marişca OT, Buja OM, Leopold LF, et al. One Step Synthesis of SERS Active Colloidal Gold Nanoparticles by Reduction with Polyethylene Glycol. Colloids Surf Physicochem Eng Asp. 2013;436:133-138.
  24. Stiufiuc R, Iacovita C, Nicoara R, Stiufiuc G, Florea A, Achim M, et al. One-Step Synthesis of PEGylated Gold Nanoparticles with Tunable Surface Charge. J Nanomater. 2013;2013:1-7.
  25. Nițică Ș, Moldovan AI, Toma V, Moldovan CS, Berindan-Neagoe I, Știufiuc G, et al. PEGylated Gold Nanoparticles with Interesting Plasmonic Properties Synthesized Using an Original, Rapid, and Easy-to-Implement Procedure. J Nanomater. 2018;2018:1-7.
  26. Danaei M, Dehghankhold M, Ataei S, Hasanzadeh Davarani F, Javanmard R, Dokhani A, et al. Impact of Particle Size and Polydispersity Index on the Clinical Applications of Lipidic Nanocarrier Systems. Pharmaceutics. 2018;10(2):57.
  27. Sahu M, Reddy VRM, Kim B, Patro B, Park C, Kim WK, et al. Fabrication of Cu2ZnSnS4 Light Absorber Using a Cost-Effective Mechanochemical Method for Photovoltaic Applications. Materials. 2022;15(5):1708.
  28. Dong J, Carpinone PL, Pyrgiotakis G, Demokritou P, Moudgil BM. Synthesis of Precision Gold Nanoparticles Using Turkevich Method. KONA Powder Part J. 2020;37:224-32.
  29. Suárez-López R, Puntes VF, Bastús NG, Hervés C, Jaime C. Nucleation and Growth of Gold Nanoparticles in the Presence of Different Surfactants: a Dissipative Particle Dynamics Study. Sci Rep. 2022;12(1):13926.
  30. Chang CH, Lin RJ, Tien CL, Yeh SM. Enhanced photoluminescence in gold nanoparticles doped homogeneous planar nematic liquid crystals. Adv Condens Matter Phys. 2018;2018:1–5.
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