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Rhazya stricta- Biosynthesized Copper Nanoparticles on Staphylococcus aureus Infected Rabbit Wounds | ||
| Iranian Journal of Veterinary Medicine | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 15 دی 1403 اصل مقاله (2.97 M) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22059/ijvm.2024.377674.1005593 | ||
| نویسندگان | ||
| Ali Hussein Aldujaily1؛ Kifah Fadhil Hassoon2؛ Douaa Barzan Salman1؛ Ghadeer S Bustani* 3 | ||
| 1Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, University of Kufa, Iraq. | ||
| 2Department of Veterinary Microbiology, Faculty of Veterinary Medicine, University of Kufa, Iraq | ||
| 3The Islamic University, Najaf, Iraq | ||
| چکیده | ||
| Nanoparticles are utilized in various technological fields, including medicine, due to their inherent antibacterial properties. Recent research has focused on the biosynthesis of copper nanoparticles (CuNPs) and their potential medical applications. OBJECTIVE This study aimed to use Rhazya stricta for the green synthesis of CuNPs and assess their effectiveness in eradicating bacterial pathogens, particularly S. aureus, and promoting wound healing in rabbits. MATERIAL AND METHODS The synthesized nanoparticles were characterized using UV-visible spectroscopy, scanning electron microscopy (SEM), Energy Dispersive Spectroscopy (EDS), X-Ray Diffraction (XRD), atomic force microscopy (AFM), and Zeta potential analysis. Fifteen rabbits were divided into three groups of five. Full-thickness costo-abdominal skin wounds were created on the right side of each rabbit. The first group served as the untreated control, the second group was treated with CuNPs, and the third group received fusidic acid treatment. RESULTS: R. stricta extract successfully synthesized CuNPs. Application of CuNPs on S. aureus-contaminated wounds showed faster healing compared to fusidic acid treatment. The CuNPs group healed in 16 days, while the fusidic acid group healed in 22 days. CuNPs-treated wounds had significantly reduced wound area, total cell count, neutrophil count, macrophage count, and lymphocyte count (P<0.05), along with increased wound contracture (P<0.05). Bacterial counts indicated that CuNPs eradicated S. aureus infections in 7 days, compared to 12 days for fusidic acid. CuNPs reduced inflammation and promoted collagen fiber deposition, leading to better healing of S. aureus-infected wounds by decreasing hemorrhagic regions and inflammatory cells. Conclusion: CuNPs synthesized using R. stricta show promising potential as a safe and effective treatment for infected wounds. They effectively eradicate infections and promote efficient wound healing, making them a viable therapeutic option for managing infected wounds. | ||
| کلیدواژه‌ها | ||
| Rhazya stricta؛ Copper nanoparticles؛ Staphylococcus aureus؛ Skin wounds؛ Histopathology | ||
| عنوان مقاله [English] | ||
| بررسی نانوذرات مس بیوسنتز شده بر روی زخم خرگوش آلوده به استافیلوکوکوس اورئوس | ||
| نویسندگان [English] | ||
| علی حسین الدجیلی1؛ کیفاه فدحیل حسون2؛ دوعا برزن سلمان1؛ غدیر صباح بوستانی3 | ||
| 1گروه علوم بالینی دامپزشکی، دانشکده دامپزشکی، دانشگاه کوفه، عراق. | ||
| 2گروه میکروبیولوژی دامپزشکی، دانشکده دامپزشکی، دانشگاه کوفه، عراق. | ||
| 3دانشگاه اسلامی، نجف، عراق | ||
| کلیدواژه‌ها [English] | ||
| نانوذرات مس, استافیلوکوکوس اورئوس, زخم های پوستی, هیستوپاتولوژی | ||
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آمار تعداد مشاهده مقاله: 24 تعداد دریافت فایل اصل مقاله: 81 |
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