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Wendel, Marvel, Carabelly, Amy, Utami, Juliyatin. (1404). An In Silico Study on Target Gene Identification and Oral Health Conditions Linked to Coal Dust Exposure. , (), -. doi: 10.22059/poll.2025.386470.2693
Marvel Wendel; Amy Nindia Carabelly; Juliyatin Putri Utami. "An In Silico Study on Target Gene Identification and Oral Health Conditions Linked to Coal Dust Exposure". , , , 1404, -. doi: 10.22059/poll.2025.386470.2693
Wendel, Marvel, Carabelly, Amy, Utami, Juliyatin. (1404). 'An In Silico Study on Target Gene Identification and Oral Health Conditions Linked to Coal Dust Exposure', , (), pp. -. doi: 10.22059/poll.2025.386470.2693
Wendel, Marvel, Carabelly, Amy, Utami, Juliyatin. An In Silico Study on Target Gene Identification and Oral Health Conditions Linked to Coal Dust Exposure. , 1404; (): -. doi: 10.22059/poll.2025.386470.2693

An In Silico Study on Target Gene Identification and Oral Health Conditions Linked to Coal Dust Exposure

Pollution
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 10 اردیبهشت 1404
نوع مقاله: Original Research Paper
شناسه دیجیتال (DOI): 10.22059/poll.2025.386470.2693
نویسندگان
Marvel Wendel1؛ Amy Nindia Carabelly* 2؛ Juliyatin Putri Utami3
1Dentistry Programme, Faculty of Dentistry, University of Lambung Mangkurat, Banjarmasin, South Kalimantan, Indonesia
2Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Lambung Mangkurat University, Banjarmasin, Indonesia
3Department of Biomedicine, Faculty of Dentistry, University of Lambung Mangkurat
چکیده
The second-largest coal-producing region in Indonesia is South Kalimantan. Coal mines have an impact on the accumulation of coal dust that flies into the residential areas of local communities. The prediction of coal dust exposure-induced genes and health conditions can be conducted through in silico study. This study is aimed to identify target genes and oral health conditions linked to coal dust exposure through an in silico study. Key coal compounds and oral health-related target genes were determined using network pharmacology analysis platforms. The datasets were downloaded from CTD database. GO and KEGG pathway enrichment analyses were performed using DAVID bioinformatics. PPI network was constructed using STRING. The disease-related genes integrative analysis was performed through CTD and HPA. Fifteen coal exposure markers were obtained to identify the gene interaction. The two main exposure markers were particulate matter and benzo(a)pyrene. There were 20 genes with more than 100 interactions selected as the coal dust exposure marker-related genes. Information on biological processes, cellular components, molecular functions, and pathway enrichment were obtained (p<0.05, FDR corrected). The PPI network was constructed. Target genes related to oral health conditions and coal dust exposure were found to be IL6, PTGS2, TNF, IL1B, CXCL8, MAPK3, TP53, RELA, CCL2, and HMOX1. The oral health conditions that were strongly linked to coal dust exposure were inflammation, necrosis, edema, pain, hyperplasia, and neoplasms. In conclusion, the main target gene identified was IL6, indicating a major role in inflammatory pathways affecting oral health conditions linked to coal dust exposure.
کلیدواژه‌ها
coal؛ environmental pollution؛ network pharmacology؛ oral health
آمار
تعداد مشاهده مقاله: 78





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