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Hanna, Demiana, Ammar, Hend, El Desouky, Mohamed A., El‐Rahman, Heba. (1404). Toxic Effects of Energy Drink Consumption on Cardiac and Renal Function in Female Wistar Rats. , (), -. doi: 10.22059/ijvm.2025.388969.1005725
Demiana Badry Hanna; Hend Ammar; Mohamed A. A. El Desouky; Heba AA El‐Rahman. "Toxic Effects of Energy Drink Consumption on Cardiac and Renal Function in Female Wistar Rats". , , , 1404, -. doi: 10.22059/ijvm.2025.388969.1005725
Hanna, Demiana, Ammar, Hend, El Desouky, Mohamed A., El‐Rahman, Heba. (1404). 'Toxic Effects of Energy Drink Consumption on Cardiac and Renal Function in Female Wistar Rats', , (), pp. -. doi: 10.22059/ijvm.2025.388969.1005725
Hanna, Demiana, Ammar, Hend, El Desouky, Mohamed A., El‐Rahman, Heba. Toxic Effects of Energy Drink Consumption on Cardiac and Renal Function in Female Wistar Rats. , 1404; (): -. doi: 10.22059/ijvm.2025.388969.1005725

Toxic Effects of Energy Drink Consumption on Cardiac and Renal Function in Female Wistar Rats

Iranian Journal of Veterinary Medicine
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 04 خرداد 1404
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22059/ijvm.2025.388969.1005725
نویسندگان
Demiana Badry Hanna* 1؛ Hend Ammar2؛ Mohamed A. A. El Desouky2؛ Heba AA El‐Rahman3
1Cairo, Giza
2Chemistry department, Science faculty, Cairo University, Cairo, Egypt
3Zoology department, Science faculty, Cairo University, Cairo, Egypt
چکیده
Objective: The current study aims to interrogate the possible toxic impacts of drinking the energy drinks (ED) on the heart and kidneys in Wister rats.
Methods: Eighteen healthy female albino rats were separated into three groups (6 rats per group). Low and high-dose groups of the tested rats received oral ED at different doses (5 and 10 ml/k g body weight/day, respectively) for 4 weeks, and distilled water was given to the control groups. Uric acid, creatinine, urea, creatine kinase, and creatine kinase-MB were measured using the colorimetric method. Moreover, DNA degradation was measured using a comet assay. Also, the inflammatory markers, including interleukin-6, were measured using ELISA. Finally, heart and kidney tissues were examined for histopathological alternation.
Result: After ED intake the results revealed there was a significant increase in Creatine kinase, creatine kinase-M B, creatinine, uric acid, and malondialdehyde interleukin-6 comparing them with the control group. In contrast, the activities of the antioxidant enzymes (superoxide dismutase, glutathione, and catalase were considerably decreased in both heart and kidney tissues in both ED-treated groups) relative to the control. Additionally, there was a considerable increase in DNA damage in low and high doses groups when compared with the control group. Lastly, ED caused a histopathological change in kidney and heart tissues.
Conclusion: Cardiac and renal damage were noticeably produced at orally exposed rats to ED. Therefore, we recommend reducing its use, and we need to study its long-term effect.
کلیدواژه‌ها
Antioxidant enzymes؛ DNA degradation؛ Energy drinks؛ Female Wistar rat؛ Inflammatory markers
آمار
تعداد مشاهده مقاله: 37





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