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Evaluation of the stress-induced alterations in hematologic indices of pregnant Wistar rats using three stress models: the health implications in offspring | ||
| Iranian Journal of Veterinary Medicine | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 29 اردیبهشت 1405 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22059/ijvm.2025.392258.1005769 | ||
| نویسندگان | ||
| Bartholomew Chukwuebuka Nwogueze* 1؛ Mary Isioma Ofili2؛ Tochukwu Nnamdi Nnama3؛ Ufuoma Jemima Mukoro2؛ Alphonsus Okafor Mbah2 | ||
| 1363 old sapele agbor | ||
| 2Department of Nursing Science, Delta State University, Abraka | ||
| 3Department of Human Anatomy, Alex Ekwueme University, Abakaliki, Ebonyi State, Nigeria. | ||
| چکیده | ||
| This study examined stress-induced alterations in hematologic indices in pregnant Wistar rats and their offspring. Sixty healthy female rats between 12-14weeks, weighing between 160-200g were used for Phase 1. Three different stress model, restraint chamber, mirror chamber, and resident intruder was used for the induction of stress. Blood samples were collected by car-diac puncture in the first, second and third weeks, respectively to estimate for the levels of total white blood cells (TWBC), red blood cells (RBC), platelet count, packed cell volume (PCV) and hemoglobin concentration (Hb). For the Phase 2 of the experiment, twelve offspring were used for the study, 6 from the control and 6 from the intruder-stressed parents (exposed 3 h daily, for 3 weeks). Blood samples were collected from offspring of stressed parents 4 weeks after birth for estimation of hematologic indices. The different stressors studied caused a significant (p<0.05) reduction in the counts of TWBC and RBC counts, while the PCV, Hb concentration and platelet counts increased. Apart from the TWBC count where the value increased significantly (p<0.05), exposure to intruder stressor decreased the counts of PCV, RBC, and platelets. The mean values of the hematologic indices of the offspring of parents exposed to intruder stressor increased, but the increase was significant (p<0.05) only with respect to PCV, Hb concentration and platelet count. The intruder stress model induced the highest intensity of stress in rats compared to the other stressors; the restraint stressor was the next, followed by mirror stressors. In conclusion, the effect of stress on hematologic indices varied during different trimesters of pregnancy and this depends on the nature, intensity and duration of stressor applied, however, the effects of stress during pregnancy on the blood para-meters of pregnant mothers cannot be transmitted to their infants, especially in the case of the intruder stressor studied. | ||
| کلیدواژهها | ||
| Hematological indices؛ Offspring؛ Pregnancy؛ Stress؛ Stressor | ||
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آمار تعداد مشاهده مقاله: 44 |
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