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مجله تحقیقات دامپزشکی (Journal of Veterinary Research) | ||
Article 12, Volume 60, Issue 1 - Serial Number 608, May 2005 PDF (542.93 K) | ||
Abstract | ||
Objective: Study on antiapoptotic effect of Deprenyl in sensory neurons of dorsal root ganglion of rat. Animals: White Sprague-Dawley rats. The regions of operation were sciatic nerve in midthigh and L dorsal root ganglion. Procedure: New born rats (3rd days) were divided into five groups and their left side sciatic nerves were transected at midthigh region. Five test groups were administered by deprenyl in different doses of: 0.1, 1, 10, 25 and50 mg/Kg and the antiapoptotic effect of drug were compared with control group. Statistical analysis: The values obtained from each test groups were compared with control group by t-test and oneway ANOVA. Results: The results showed that treatment of animal with deprenyl prevented reduction in neurons number, in dose dependent manner.The group treated with dose 25mg/Kg showed the better results. Conclusion: Deprenyl is able to prevent the induction of apoptosis in axotomized and nonaxotomized neurons J.Fac. Vet.Med.Univ.Tehran. 60,1:65-69,2005 | ||
Keywords | ||
Apoptosis; Axotomy; Deprenyl; Dorsal Root Ganglion | ||
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