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Synthesis of 4-(2-Methylthiazol-4-yl)-Hexahydroquinoline and 1,4-Dihydropyrimidin Derivatives | ||
| Journal of Sciences, Islamic Republic of Iran | ||
| مقاله 3، دوره 22، شماره 1، خرداد 2011، صفحه 21-45 اصل مقاله (4.69 M) | ||
| نویسنده | ||
| A. Shafiee | ||
| Tehran University of Medical Sciences | ||
| چکیده | ||
| A series of new hexahydroquinoline and 1,4-dihydropyrimidine derivatives were synthesized. Condensation of 2-methyl- thiazole-4-carboxaldehyde (1) with 1,3-cyclohexanedione and alkyl 3- aminocrotonate afforded 4-(2-methyl-thiazol-4-yl)-hexahydroquinoline while condensation of aldehyde (1) with benzoyl acetone and thiourea gave 1,4-dihydropyrimidine derivatives. The stereochemistry of 1,4-dihydropyrimidine derivatives were studied using 1HNMR. | ||
| کلیدواژه‌ها | ||
| 1؛ 4-Dihydropyrimidines؛ 4-Hexahydroquinoline؛ Thiazoles؛ 1-4-Dihydropyridine | ||
| عنوان مقاله [English] | ||
| Synthesis of 4-(2-Methylthiazol-4-yl)-Hexahydroquinoline and 1,4-Dihydropyrimidin Derivatives | ||
| نویسندگان [English] | ||
| A. Shafiee | ||
| چکیده [English] | ||
| A series of new hexahydroquinoline and 1,4-dihydropyrimidine derivatives were synthesized. Condensation of 2-methyl- thiazole-4-carboxaldehyde (1) with 1,3-cyclohexanedione and alkyl 3- aminocrotonate afforded 4-(2-methyl-thiazol-4-yl)-hexahydroquinoline while condensation of aldehyde (1) with benzoyl acetone and thiourea gave 1,4-dihydropyrimidine derivatives. The stereochemistry of 1,4-dihydropyrimidine derivatives were studied using 1HNMR. | ||
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آمار تعداد مشاهده مقاله: 1,531 تعداد دریافت فایل اصل مقاله: 3,053 |
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