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| بین المللی علوم (منتشر نمی شود) | ||
| مقاله 7، دوره 6، شماره 0 - شماره پیاپی 1374، اردیبهشت 1384 اصل مقاله (197.36 K) | ||
| نویسندگان | ||
| E. Khoshbin؛ R.B. Davies* | ||
| عنوان مقاله [English] | ||
| - | ||
| چکیده [English] | ||
| Background: As Motor Neuron Disease (MND) involves a progressive deterioration in nerve function, it is possible that risk factors for the disease will also accelerate the progression of the disease. Methods: This paper uses the two stages of age at onset and age at death to measure progression. Conventional parametric survival models are used to identify significant covariate from a large number of variables which have been suggested as risk factors for “MND / Frailty” models are used to characterize more fully the two stage progression process. Results and Conclusions: The results suggest the polluted work environments are associated with early onset of MND. Although there is a negative dependence between duration from onset to death and age at onset, this is not necessarily inconsistent with the expected progressive deterioration; there is a tantalizing suggestion from the frailty modeling that this may be the net result of a positive association due to variation in the rate of progression over the population and a negative association due to the direct effect of age (for example, because the elderly are more at risk from infections). | ||
| کلیدواژهها [English] | ||
| frailty models, MND, true and spurious temporal dependence | ||
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آمار تعداد مشاهده مقاله: 1,158 تعداد دریافت فایل اصل مقاله: 1,023 |
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