تعداد نشریات | 158 |
تعداد شمارهها | 6,228 |
تعداد مقالات | 67,740 |
تعداد مشاهده مقاله | 115,071,620 |
تعداد دریافت فایل اصل مقاله | 89,800,932 |
NITROIMIDAZOLES 111. [I]. SYNTHESIS, ANTIBACT - ERIAL AND ANTIFUNGAL ACTIVITY OF ZMETHYL - SU LFONYL -5 -(I-METHYL -5- NITRO-2- IMIDAZOLYL) 1,3,4-THIADIAZOLE | ||
Journal of Sciences, Islamic Republic of Iran | ||
مقاله 11، دوره 1، شماره 1، اسفند 1989 اصل مقاله (237.11 K) | ||
چکیده | ||
2- Methylsulfonyl - 5- (1-methyl-5-nitro- 2 – imidazolyl ) 1,3,4 - thiadiazole ( 1 ) was prepared by twa independent routes.1) reaction of 1-methyl-2-formyl-5- nitroimidazole (3) with methyl hydrazinecarbodithioate gave the hydrazone 4. Reaction of compound 4 with acetic anhydride followed by potassium permanganate oxidation of the intermediate 5 gave the desired compound 1. 2) Reaction of thiourea with 2–chloro–5-(l-methyl-5-nitro-2-imidazolyl) 1,3, 4 – thiadiazole (7) gave the thiol 8. Reaction of the latter with methyl iodide in alkaline medium followed by potassium permanganate oxidation afforded also compound 1. The antibacterial and antifungal activity of compound 1 against a number of microorganisms were determined .Compound 1 showed significant antibacterial and antifungal activity | ||
عنوان مقاله [English] | ||
- | ||
چکیده [English] | ||
0 | ||
آمار تعداد مشاهده مقاله: 903 تعداد دریافت فایل اصل مقاله: 607 |