EFFECT OF TOXOCARA CANIS SECOND STAGE LARVAE ON THE HOST IMMUNE SYSTEM | ||
| Journal of Sciences, Islamic Republic of Iran | ||
| مقاله 2، دوره 1، شماره 3، 1990 اصل مقاله (418.57 K) | ||
| چکیده | ||
| We have studied functional alteration of immunocytes in mice following inoculation of Toxocara canis second stage larvae. Results indicated depression of lymphocyte blastogenesis in response to concanavalin-A, phytohemagglutinin and allogeneic non B-cells; however, B-cell polyclonal activation was not affected as indicated by the production of total IgG. In contrast, frequency of antibody secreting cells was reduced. Similarly, interleukin-1 and interleukin-2 production were not affected by Toxocara canis infection. Furthermore, spleen cells of infected mice synthesized more prostaglandin E than uninfected animals. This data suggests that Toxocara canis infection induces suppression of both cell mediated and humoral immunity; perhaps due to an increase of prostoglandin E2 production. | ||
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