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SYNTHESES, ANTIFUNGAL AND ANTIBACTERIAL ACTIVITIES OF SUBSTITUTED 1,2, CTRIMOLES | ||
Journal of Sciences, Islamic Republic of Iran | ||
مقاله 7، دوره 9، شماره 1، خرداد 1998 اصل مقاله (239.83 K) | ||
چکیده | ||
The reaction of readily available 1 -methyl-4-nitropyrrole-2- carboxylic acid (1) with thionyl chloride afforded the corresponding acyl chloride 2. The reaction of compound 2 with thiosemicarbazides yielded 1-(1 -methyl-4-nitrop yrrole-2-carbony1)- thiosemicarbazides (3) which cyclized in basic medium to 5-(1-methyl-4-nitropyrrole- 2-y1)-2,4-dihydro-3H- l,2,4-triazole-3- thione 4. Alkylation and subsequent oxidation of 4 gave 6. The antibacterial and antifungal activities of 6a to 6f against a number of microorganisms were determined. Only compounds 6b and 6c had moderate activity against Aspergilus niger | ||
عنوان مقاله [English] | ||
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چکیده [English] | ||
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آمار تعداد مشاهده مقاله: 741 تعداد دریافت فایل اصل مقاله: 744 |