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NITROIMIDAZOLES VII [I]. SYNTHESES, ANTIBACTERIAL AND ANTIFUNGAL ACT I V I T I E S OF 4 - S U B S T I T U T E D - 2 - TWIAZOLYLHYDRAZONES | ||
| Journal of Sciences, Islamic Republic of Iran | ||
| مقاله 7، دوره 1، شماره 2، خرداد 1990 اصل مقاله (251.73 K) | ||
| چکیده | ||
| Reaction of readily available 2-formyl -1-methyl-5-nitroimidazole (1) with 4-substituted-2-hydrazinothiazoles (2) afforded 2-formyl-l-methyl-5- nitroimidazole 4-substituted -2- thiazolylhydrazones (3). Reaction of thiochromitn-4-one (4) with thiosemicarbazide gave thiochroman-4- one thiosemicarbazone (5). Reaction of compound 5 with clc- haloaldehyde or ketones y ielded thiochroman--#-one 4-substituted-2-thiazolylhydrozones(6). The antibacterial and antifungal activities of compounds 3 and 6 against a number of microorganisms were determined | ||
| عنوان مقاله [English] | ||
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| چکیده [English] | ||
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