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SYNTHESES, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF 2-ARYL-4- QUINOLINE- CARBOXAMIDE DERIVATIVES | ||
Journal of Sciences, Islamic Republic of Iran | ||
مقاله 8، دوره 4، شماره 2، شهریور 1993 اصل مقاله (765.31 K) | ||
چکیده | ||
Reaction of aryl methyl ketone with isatin in the presence of a base afforded 2- arylquinoline-4-carboxylic acid (3). Reaction of diazomethane with compound 3 yielded the ester 4. Compound 5 was prepared from the reaction of N, N'-dialkylethyl (or propyl) arnine with 4. Addition of hydrazine hydrate to compound 4a gave 2- (2- pyridyl) quinoline-4-carboxylic acid hydrazide (6). Reaction of l-methyl-5- nitroimidazole-2-carboxaldehyde (7) with 6 in ethanol afforded compound 8 in good yield. The antibacterial and antifungal activities of compounds 5,6 and 8 were determined | ||
عنوان مقاله [English] | ||
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چکیده [English] | ||
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