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Synthesis of some New Thiosemicarbazide and 1,3,4-Thiadiazole Heterocycles Bearing Benzo[b]Thiophene Nucleus as a Potent Antitubercular and Antimicrobial Agents | ||
Journal of Sciences, Islamic Republic of Iran | ||
مقاله 6، دوره 16، شماره 1، خرداد 2005 اصل مقاله (145.68 K) | ||
چکیده | ||
Reaction of 2-hydrazinocarbonyl-3-chloro-5-phenoxy-benzo[b] thiophene with different substituted phenyl isothiocyanate gave N-substituted arylthiosemi-carbazide derivatives (1a-h). 1,3,4-Thiadiazole derivatives (2a-h) were prepared by the cyclization of arylthiosemicarbazides (1a-h) with concentrated sulphuric acid. All the compounds were screened for their antitubercular activity against Mycobacterium tuberculosis (H37Rv) and antimicrobial activity against various microorganisms | ||
عنوان مقاله [English] | ||
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چکیده [English] | ||
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