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SYNTHESIS OF 4-(1-BENZYL-5-IMIDAZOLYL)-1,4-DIHYDROPYRIDINES | ||
Journal of Sciences, Islamic Republic of Iran | ||
مقاله 4، دوره 13، شماره 1، خرداد 2002 اصل مقاله (75.47 K) | ||
چکیده | ||
The o-nitrophenyl group at position 4 of dihydropyridine of nifedipine analogues was replaced with 2-alkylthio-1-benzyl-5-imidazolyl substituent. Starting from dihydroxyacetone 2-alkythio-1-benzyl- 5-formyl imidazole (3) was first synthesized which was subsequently used in synthesizing symmetrical (5a-f) and asymmetrical (6a,b) dihydropyridines. Primarily pharmacological studies of the title compounds have shown they have good calcium channel antagonist activities. | ||
عنوان مقاله [English] | ||
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چکیده [English] | ||
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آمار تعداد مشاهده مقاله: 704 تعداد دریافت فایل اصل مقاله: 734 |