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Analysis of Exon 19 and 39 of ATM Gene in Brain Tumors; Considering the P53 Accumulation | ||
| Journal of Sciences, Islamic Republic of Iran | ||
| مقاله 2، دوره 19، شماره 3، آذر 2008 اصل مقاله (649.53 K) | ||
| چکیده | ||
| Many studies have been focused on cytogenetic and molecular genetic defects in brain tumors; therefore the role of ATM as a tumor suppressor gene in these tumors is poorly considered. In this study mutation analysis of exon 19 and 39 of ATM gene and P53 accumulation were investigated by PCR-SSCP, sequencing, and flow cytometry . Four polymorphisms including D1853N, IVS 38-8 T?C, F858L, P872T were reported for the first time in brain tumors other than medulloblastoma. Expression of P53 could be detected in more than 10% of cells in patients affected with meningioma and 4.08% and 3.46% of cells inastrocytoma and chordoma respectively. The present findings could confirm the importance of ATM gene alterations in tumor genesis of brain tumors and further investigation is essential. | ||
| عنوان مقاله [English] | ||
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| چکیده [English] | ||
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آمار تعداد مشاهده مقاله: 1,074 تعداد دریافت فایل اصل مقاله: 1,452 |
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