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M. H., Moshafi, Bahador, N., Moghimi, S., Ejtemaei, R., Foroumadi, A., A., Asadipour. (1396). Novel Levofloxacin Derivatives as Potent Antibacterial Agents. , 28(2), 127-131.
Moshafi M. H.; N. Bahador; S. Moghimi; R. Ejtemaei; A. Foroumadi; Asadipour A.. "Novel Levofloxacin Derivatives as Potent Antibacterial Agents". , 28, 2, 1396, 127-131.
M. H., Moshafi, Bahador, N., Moghimi, S., Ejtemaei, R., Foroumadi, A., A., Asadipour. (1396). 'Novel Levofloxacin Derivatives as Potent Antibacterial Agents', , 28(2), pp. 127-131.
M. H., Moshafi, Bahador, N., Moghimi, S., Ejtemaei, R., Foroumadi, A., A., Asadipour. Novel Levofloxacin Derivatives as Potent Antibacterial Agents. , 1396; 28(2): 127-131.

Novel Levofloxacin Derivatives as Potent Antibacterial Agents

Journal of Sciences, Islamic Republic of Iran
مقاله 4، دوره 28، شماره 2، تیر 2017، صفحه 127-131    اصل مقاله (209.86 K)
نوع مقاله: Final File
نویسندگان
Moshafi M. H.1؛ N. Bahador1؛ S. Moghimi2؛ R. Ejtemaei2؛ A. Foroumadi3؛ Asadipour A.* 4
11Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutics Research Center, Kerman University of Medical Sciences, Kerman, Islamic Republic of Iran
22Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran
32Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran+/3Department of Medicinal Chemistry, Faculty of Pharmacy and Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Islamic Republic of Iran
43Department of Medicinal Chemistry, Faculty of Pharmacy and Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Islamic Republic of Iran
چکیده
In this report, a new series of fluoroquinolone agents which was derived from levofloxacin was synthesized and evaluated against Gram-positive (Bacillus subtillis, Staphylococcus aureus, Staphylococcus epidermidis and Micrococcus luteus) and Gram-negative (Esherichio coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Serratia marcescens) organisms. The results showed that some of the synthesized compounds are strong antibacterial agents. All the synthesized compounds showed remarkable activities against Staphylococcus epidermidis and Staphylococcus aureus (MIC = 0.03-1 µg/mL and 0.06-1 µg/mL respectively).
کلیدواژه‌ها
Antibacterial evaluation؛ Fluoroquinolone؛ Levofloxacin
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