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Sharifi, S., Pakdel, A., Ebrahimie, E. (2017). Meta-analysis of transcriptomic data of mammary gland infected by Escherichia coli Bacteria in dairy cows. , 48(3), 343-352. doi: 10.22059/ijas.2017.232123.653524
Somayeh Sharifi; Abbas Pakdel; Esmaeil Ebrahimie. "Meta-analysis of transcriptomic data of mammary gland infected by Escherichia coli Bacteria in dairy cows". , 48, 3, 2017, 343-352. doi: 10.22059/ijas.2017.232123.653524
Sharifi, S., Pakdel, A., Ebrahimie, E. (2017). 'Meta-analysis of transcriptomic data of mammary gland infected by Escherichia coli Bacteria in dairy cows', , 48(3), pp. 343-352. doi: 10.22059/ijas.2017.232123.653524
Sharifi, S., Pakdel, A., Ebrahimie, E. Meta-analysis of transcriptomic data of mammary gland infected by Escherichia coli Bacteria in dairy cows. , 2017; 48(3): 343-352. doi: 10.22059/ijas.2017.232123.653524

Meta-analysis of transcriptomic data of mammary gland infected by Escherichia coli Bacteria in dairy cows

علوم دامی ایران
Article 4, Volume 48, Issue 3, December 2017, Pages 343-352    PDF (479.44 K)
Document Type: Research Paper
DOI: 10.22059/ijas.2017.232123.653524
Authors
Somayeh Sharifi1; Abbas Pakdel* 2; Esmaeil Ebrahimie3
1Ph. D. Candidate, Faculty of Agriculture, Isfahan University of Technology, Isfahan, Iran
2Associate Professor, Faculty of Agriculture, Isfahan University of Technology, Isfahan, Iran
3Associate Professor, Institute of Biotechnology, Shiraz Univeristy, Shiraz, Iran, and School of Biological Science, Faculty of Science and Engineering, Flinders University of Adelaide, Australia
Abstract
Identification of disease-causing genes that underlie complex traits such as susceptibility to disease not only can improve diagnosis and the prevention of illness, but also help breeder to select resistance animals against diseases. In the current study to aim the higher power of statistical analysis to identification of genes and biological pathways related to mastitis disease, we used Fisher meta-analysis to combine p-values obtained from individual analysis of datasets extracted from 6 microarray-based studies which investigate transcriptomic data of mammary gland tissue infected by Escherichia coli (E. coli) in dairy cows. Identification of genes that did not show a significant p-value in any of the independent studies may confirm the aim and lead to introduce a more complete set of biological pathways involved in this disease such as the pathways related to immune response, inflammation, proteolysis, growth, and death of cell. Positive regulation of transcription from RNA polymerase II promoter, is new pathways related to this disease which despite of the enrichment by maximum number of up-regulated genes in this study, have not been reported in previous mastitis studies.
Keywords
Dairy Cows; Differential express gene; Escherichia coli; gene ontology; Mastitis
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