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مقصودی, صابر محمد, مهربانی یگانه, حسن, نجاتی جوارمی, اردشیر. (1397). شناسایی نواحی تحت انتخاب مثبت در ژنگان اسب‌های کرد و عرب ایرانی با استفاده از روش مبتنی بر نامتعادلی پیوستگی ژنی. , 49(2), 321-333. doi: 10.22059/ijas.2018.259151.653640
صابر محمد مقصودی; حسن مهربانی یگانه; اردشیر نجاتی جوارمی. "شناسایی نواحی تحت انتخاب مثبت در ژنگان اسب‌های کرد و عرب ایرانی با استفاده از روش مبتنی بر نامتعادلی پیوستگی ژنی". , 49, 2, 1397, 321-333. doi: 10.22059/ijas.2018.259151.653640
مقصودی, صابر محمد, مهربانی یگانه, حسن, نجاتی جوارمی, اردشیر. (1397). 'شناسایی نواحی تحت انتخاب مثبت در ژنگان اسب‌های کرد و عرب ایرانی با استفاده از روش مبتنی بر نامتعادلی پیوستگی ژنی', , 49(2), pp. 321-333. doi: 10.22059/ijas.2018.259151.653640
مقصودی, صابر محمد, مهربانی یگانه, حسن, نجاتی جوارمی, اردشیر. شناسایی نواحی تحت انتخاب مثبت در ژنگان اسب‌های کرد و عرب ایرانی با استفاده از روش مبتنی بر نامتعادلی پیوستگی ژنی. , 1397; 49(2): 321-333. doi: 10.22059/ijas.2018.259151.653640

شناسایی نواحی تحت انتخاب مثبت در ژنگان اسب‌های کرد و عرب ایرانی با استفاده از روش مبتنی بر نامتعادلی پیوستگی ژنی

علوم دامی ایران
مقاله 14، دوره 49، شماره 2، شهریور 1397، صفحه 321-333    اصل مقاله (635.42 K)
نوع مقاله: مقاله پژوهشی
شناسه دیجیتال (DOI): 10.22059/ijas.2018.259151.653640
نویسندگان
صابر محمد مقصودی1؛ حسن مهربانی یگانه* 2؛ اردشیر نجاتی جوارمی3
1دانشجوی دکتری، پردیس کشاورزی و منابع طبیعی دانشگاه تهران، کرج
2دانشیار، پردیس کشاورزی و منابع طبیعی دانشگاه تهران، کرج
3استاد، پردیس کشاورزی و منابع طبیعی دانشگاه تهران، کرج
چکیده
اسب­های عرب به داشتن عملکرد خوب در مسابقه‌های استقامتی، پرش و زیبایی شهرت دارند. اسب­های کرد بومی منطقه‌های کوهستانی غرب ایران، مناسب مسابقه‌های چوگان هستند. اسب­های کرد، قد کوتاه­تر و وزن سنگین­تری نسبت به اسب­های عرب دارند. در این بررسی آمارۀ XP-EHH که مبتنی بر نامتعادلی پیوستگی ژنی (لینکاژی) است برای شناسایی قطعه‌های کروموزومی تحت انتخاب در ژنگان (ژنوم) اسب­های کرد و عرب ایرانی استفاده شد. برای این منظور، از نمونۀ خون و مو 38 اسب عرب و 58 اسب کرد DNA ژنگانی استخراج شد. همۀ نمونه­ها DNA توسط آرایۀ Axiom MNEC670 تعیین نژادگان (ژنوتیپ) شدند. پس از پالایش داده‌ها آمارۀ XP-EHH محاسبه شد. در اسب­های عرب 51 جایگاه (85 ژن) و در اسب‌های کرد 7 جایگاه (13 ژن) تحت انتخاب شناسایی شد. نواحی تحت انتخاب در اسب­های عرب با مسیرهای درگیر در سامانۀ ایمنی، تشکیل پروتئین شیر، رشد و نمو و سوخت‌وساز (متابولیسم) ماهیچه، بینایی، شبکۀ عصبی و اندازۀ بدن مرتبط بودند درحالی‌که در اسب­های کرد با مسیر گیرندۀ جفت‌شونده با پروتئین G، رشد و بلوغ فیبرهای ماهیچه، تنظیم خون بندآوری (هموستازی) اکسیژن یاخته‌ای، رنگدانه­سازی در پوست و مو ارتباط داشتند.
کلیدواژه‌ها
اسب عرب ایرانی؛ نژاد اسب کرد؛ XP-EHH؛ نشانه‌های انتخاب
عنوان مقاله [English]
Identification of positive selection signatures in Iranian Kurdish and Arabian horses by linkage disequilibrium-based method
نویسندگان [English]
Saber Mohammad Maghsoodi1؛ Hassan Mehrabani Yeganeh2؛ Ardeshir Nejati Javaremi3
1Ph.D. Candidate, College of Agriculture & Natural Resources, University of Tehran, Karaj, Iran
2Associate Professor, College of Agriculture & Natural Resources, University of Tehran, Karaj, Iran
3Professor, College of Agriculture & Natural Resources, University of Tehran, Karaj, Iran
چکیده [English]
The Arab horses are famous for endurance riding, jumping and beauty. Kurdish horses are native to hilly regions of west of Iran and they are suitable for Polo tournament. Kurdish horses are shorter and heavier than Arabian horses. In this study, we use the linkage disequilibrium-based method, XP-EHH statistic, for Identification of regions that have undergone selection in the genome of Arabian and Kurdish horses. For this purpose, genomic DNA from blood and hair samples from 38 Arabian and 58 Kurdish horses were extracted. All DNA samples genotyped by the Axiom MNEC670 array. After data pruning, XP-EHH statistic was calculated. We identified 51 genomic regions (85 genes) in Iranian Arab horses and 7 genomic regions (13 genes) in Kurdish horses showing signatures of selection. We found positively selected genomic regions in the Iranian Arab horses associated with immune system related pathways, milk protein formation, muscle growth and development, vision, nervous system and body size whereas in the Kurdish horses associated with G protein–coupled receptors, growth and maturation of muscle fibers, cellular oxygen homeostasis and skin and hair pigmentation.
کلیدواژه‌ها [English]
Iranian Arab horse, Kurdish horse, selection signatures, XP-EHH
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