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مخبر, مهدی, مرادی شهربابک, محمد, صادقی, مصطفی, مرادی شهربابک, حسین, رحمانی نیا, جواد. (1398). جستجوی نشانه‌های انتخاب بین گاومیش‌های آذری و مازندرانی با استفاده از نشانگرهای SNP با تراکم زیاد. , 50(2), 89-102. doi: 10.22059/ijas.2017.228562.653514
مهدی مخبر; محمد مرادی شهربابک; مصطفی صادقی; حسین مرادی شهربابک; جواد رحمانی نیا. "جستجوی نشانه‌های انتخاب بین گاومیش‌های آذری و مازندرانی با استفاده از نشانگرهای SNP با تراکم زیاد". , 50, 2, 1398, 89-102. doi: 10.22059/ijas.2017.228562.653514
مخبر, مهدی, مرادی شهربابک, محمد, صادقی, مصطفی, مرادی شهربابک, حسین, رحمانی نیا, جواد. (1398). 'جستجوی نشانه‌های انتخاب بین گاومیش‌های آذری و مازندرانی با استفاده از نشانگرهای SNP با تراکم زیاد', , 50(2), pp. 89-102. doi: 10.22059/ijas.2017.228562.653514
مخبر, مهدی, مرادی شهربابک, محمد, صادقی, مصطفی, مرادی شهربابک, حسین, رحمانی نیا, جواد. جستجوی نشانه‌های انتخاب بین گاومیش‌های آذری و مازندرانی با استفاده از نشانگرهای SNP با تراکم زیاد. , 1398; 50(2): 89-102. doi: 10.22059/ijas.2017.228562.653514

جستجوی نشانه‌های انتخاب بین گاومیش‌های آذری و مازندرانی با استفاده از نشانگرهای SNP با تراکم زیاد

علوم دامی ایران
مقاله 1، دوره 50، شماره 2، شهریور 1398، صفحه 89-102    اصل مقاله (1.03 M)
نوع مقاله: مقاله پژوهشی
شناسه دیجیتال (DOI): 10.22059/ijas.2017.228562.653514
نویسندگان
مهدی مخبر* 1؛ محمد مرادی شهربابک2؛ مصطفی صادقی3؛ حسین مرادی شهربابک4؛ جواد رحمانی نیا5
1استادیار، گروه علوم دامی دانشگاه ارومیه، ارومیه، ایران
2استاد، پردیس کشاورزی و منابع طبیعی دانشگاه تهران، کرج، ایران
3دانشیار، پردیس کشاورزی و منابع طبیعی دانشگاه تهران، کرج، ایران
4استادیار، پردیس کشاورزی و منابع طبیعی دانشگاه تهران، کرج، ایران
5استادیار، مؤسسه تحقیقات علوم دامی کشور، سازمان تحقیقات، آموزش و ترویج کشاورزی، کرج، ایران
چکیده
به­منظور یافتن نشانه­های انتخاب بر روی ژنوم گاومیش از 287 رأس گاومیش رودخانه­ای شامل 260 رأس آذری و 27 رأس مازندرانی استفاده شد. ژنوتیپ نمونه­ها به­وسیله­ آرایه­های ژنومی Axiom® Buffalo Genotyping 90K تعیین شد و برآوردگر نااریب FST (θ) برای یافتن نشانه­های انتخاب مورد استفاده قرار گرفت. در مجموع 14 منطقه که نشانگرهای SNP آن­ها بالاتر از 1/0 درصد حد بالای توزیع تجربی FST بودند، به­عنوان نشانه­های انتخاب شناسایی شدند. بعد از انطباق مناطق ژنومی انتخاب شده با مناطق­ژنومی متناظر آن روی ژنوم گاو (UMD3.1 Bos Taurus Genome)، 105 ژن و 28 QTL شناسایی شد. از مجموع 105 ژن شناسایی شده در مناطق ژنومی تحت­ انتخاب، 27 ژن مربوط به گیرنده­های بویایی بودند. همچنین یک­سری از ژن­های شناسایی شده در رشد و توسعه بافت­های بدنی، مرگ­و­میر سلولی، سیستم ایمنی بدن و توسعه بافت­های پستانی نقش دارند. بررسی­ها هم­چنین نشان داد که QTL­های شناسایی شده در این مطالعه عمدتاً با صفات مربوط به رشد از قبیل وزن بدن در تولد، شیرگیری و بلوغ، چربی زیرپوستی، تولید گوشت لخم و وزن لاشه ارتباط دارد. QTL­های مرتبط با تولید شیر، فقط با کیفیت شیر و تعداد سلول­های شیر ارتباط دارند. در هر صورت، توصیه می­شود جهت شناسایی نقش دقیق این ژن­ها و QTL­ها بایستی مطالعات ارتباطی انجام گیرد.
کلیدواژه‌ها
آرایه‌های ژنومی؛ شاخص تمایز جمعیتی؛ گاومیش آذری و مازندرانی
عنوان مقاله [English]
Detection of selection signatures in Azeri and Mazandrani buffalo populations by high density SNP markers
نویسندگان [English]
Mahdi Mokhber1؛ Mohammad Moradi Shahre Babak2؛ Mostafa Sadeghi3؛ Hossein Moradi Shahrbabak4؛ Javad Rahmani-Nia5
1Assistant Professor, Department of Animal Science, Faculty of Agricultural Science, Urmia university, Urmia, Iran
2Professor, Department of Animal Science, College of Agriculture & Natural Resources (UTCAN), University of Tehran, Karaj, Iran
3Associated Professor, Department of Animal Science, College of Agriculture & Natural Resources (UTCAN), University of Tehran, Karaj, Iran
4Assistant Professor, Department of Animal Science, College of Agriculture & Natural Resources (UTCAN), University of Tehran, Karaj, Iran
5Assistant Professor, Department of Animal Breeding and Genetics, Animal Science Research institute of Iran (ASRI), Karaj, Iran
چکیده [English]
In order to detect signature of selection on buffalo genome, a set of 287 water buffalo samples from 260 Azari and 27 Mazandarani buffalo breeds were genotyped using the Axiom® Buffalo Genotyping 90K Array. The unbiased fixation index method (FST) was used to detect signatures of selection. In total, 14 regions with outlier FST values (0.1%) were identified. Annotation of these regions using the UMD3.1 Bos taurus Genome Assembly was performed to find putative candidate genes and QTLs within the selected and 105 genes and 28 QTLs with selection signatures were detected. A high proportion of identified genes (N=27) in regions under selection were involved in olfactory receptor, also some of the detected genes were associated with growth and body development, metabolicand apoptosis possesses, immune system development, and mammary gland development. Some of the identified QTLs in regions under selection were associated with growth traits such as body weight at birth, weaning and mature, subcutaneous fat, meat yield and carcass weight. The detected QTL for milk traits were only associated with milk contents and somatic cell count. However, it is recommended to carry out association studies to show the actual function of these genes.
کلیدواژه‌ها [English]
Azeri and Mazandrani buffalo breeds, Genotyping Array, population differentiation index
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