سامانه پشتیبانی خدمات اطلاعات

  اخبار و اعلانات

 آمار

تعداد نشریات158
تعداد شماره‌ها6,230
تعداد مقالات67,755
تعداد مشاهده مقاله115,095,162
تعداد دریافت فایل اصل مقاله89,847,209
Malekzadeh, Roya, Arjmand, Mohammad, Haji Hosseini, Reza, Vaziri, Atusa, Zamani, Zahra. (1399). Evaluation of the Anticancer Effect of Xanthium Strumarium Root Extract on Human Epithelial Ovarian Cancer Cells Using 1H NMR-Based Metabolomics. , 31(3), 205-212. doi: 10.22059/jsciences.2020.291407.1007458
Roya Malekzadeh; Mohammad Arjmand; Reza Haji Hosseini; Atusa Vaziri; Zahra Zamani. "Evaluation of the Anticancer Effect of Xanthium Strumarium Root Extract on Human Epithelial Ovarian Cancer Cells Using 1H NMR-Based Metabolomics". , 31, 3, 1399, 205-212. doi: 10.22059/jsciences.2020.291407.1007458
Malekzadeh, Roya, Arjmand, Mohammad, Haji Hosseini, Reza, Vaziri, Atusa, Zamani, Zahra. (1399). 'Evaluation of the Anticancer Effect of Xanthium Strumarium Root Extract on Human Epithelial Ovarian Cancer Cells Using 1H NMR-Based Metabolomics', , 31(3), pp. 205-212. doi: 10.22059/jsciences.2020.291407.1007458
Malekzadeh, Roya, Arjmand, Mohammad, Haji Hosseini, Reza, Vaziri, Atusa, Zamani, Zahra. Evaluation of the Anticancer Effect of Xanthium Strumarium Root Extract on Human Epithelial Ovarian Cancer Cells Using 1H NMR-Based Metabolomics. , 1399; 31(3): 205-212. doi: 10.22059/jsciences.2020.291407.1007458

Evaluation of the Anticancer Effect of Xanthium Strumarium Root Extract on Human Epithelial Ovarian Cancer Cells Using 1H NMR-Based Metabolomics

Journal of Sciences, Islamic Republic of Iran
مقاله 1، دوره 31، شماره 3، آذر 2020، صفحه 205-212    اصل مقاله (905.58 K)
نوع مقاله: Original Paper
شناسه دیجیتال (DOI): 10.22059/jsciences.2020.291407.1007458
نویسندگان
Roya Malekzadeh1؛ Mohammad Arjmand* 2؛ Reza Haji Hosseini3؛ Atusa Vaziri4؛ Zahra Zamani5
1Metabolomics Lab. Biochemistry Dept. Pasteur INstitute of Iran, Dept. Of Biology, Payame Noor University, Tehran, Iran
2Metabolomics Lab. Biochemistry Dpt. Pasteur Institute of Iran
3Dept. of Biology, Payame Noor University, Tehran, Iran
4Dept. of Biology, Payame Noor University, Tehran, Iran
5Metabolomics Lab. Biochemistry Dept. Pasteur Institute of Iran, Tehran, Iran
چکیده
Epithelial Ovarian cancer is the leading cause of cancer mortality among women all over the world. As chemotherapeutics has many side effects, researchers have focused on the potential use of medicinal plants as natural antitumor agents. Xanthium strumarium studied in this work as an herbal anticancer agent. This study aimed to evaluate the antitumor effect and metabolic alterations caused by the root extract of X. strumarium on human ovarian cancer cell line (A2780cp), using NMR-based metabolomics approaches. Cells were cultured and treated with different concentrations of the ethanolic plant extract. Antitumor activity determined by MTT assay and cell metabolites extracted for NMR spectroscopy. 1H NMR spectroscopy was applied, and outliers were analyzed using multivariate statistical analysis techniques. The extract exhibited antitumor activity against ovarian cancer cells with an IC50 of 6 μg/ml after 48 hours of treatment. The most affected metabolic pathways in the experimental groups were limited to tyrosine metabolism, nucleotide metabolism, fatty acid biosynthesis, and glycerolipid metabolism. Our data showed that the ethanolic root extract of X. strumarium has antitumor activity on the ovarian cancer cells and can affect vital metabolic pathways. However, further studies required to validate this activity.
کلیدواژه‌ها
Xanthium strumarium؛ Epithelial ovarian cancer؛ A2780cp cell line؛ Metabolomics؛ 1H NMR
آمار
تعداد مشاهده مقاله: 1,281
تعداد دریافت فایل اصل مقاله: 618


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب