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naderi, ehsan, Naseri, Mahmoud, Taimouri Rad, Heidar, Zolfaghari Emameh, Reza, Farnoosh, Gholamreza, Taheri, Ramezan Ali. (1399). In vivo and In vitro Biocompatibility Study of Fe3O4@ZnO and Fe3O4@SiO2 as Photosensitizer for Targeted Breast Cancer Drug Delivery. , 31(4), 357-368. doi: 10.22059/jsciences.2020.308691.1007559
ehsan naderi; Mahmoud Naseri; Heidar Taimouri Rad; Reza Zolfaghari Emameh; Gholamreza Farnoosh; Ramezan Ali Taheri. "In vivo and In vitro Biocompatibility Study of Fe3O4@ZnO and Fe3O4@SiO2 as Photosensitizer for Targeted Breast Cancer Drug Delivery". , 31, 4, 1399, 357-368. doi: 10.22059/jsciences.2020.308691.1007559
naderi, ehsan, Naseri, Mahmoud, Taimouri Rad, Heidar, Zolfaghari Emameh, Reza, Farnoosh, Gholamreza, Taheri, Ramezan Ali. (1399). 'In vivo and In vitro Biocompatibility Study of Fe3O4@ZnO and Fe3O4@SiO2 as Photosensitizer for Targeted Breast Cancer Drug Delivery', , 31(4), pp. 357-368. doi: 10.22059/jsciences.2020.308691.1007559
naderi, ehsan, Naseri, Mahmoud, Taimouri Rad, Heidar, Zolfaghari Emameh, Reza, Farnoosh, Gholamreza, Taheri, Ramezan Ali. In vivo and In vitro Biocompatibility Study of Fe3O4@ZnO and Fe3O4@SiO2 as Photosensitizer for Targeted Breast Cancer Drug Delivery. , 1399; 31(4): 357-368. doi: 10.22059/jsciences.2020.308691.1007559

In vivo and In vitro Biocompatibility Study of Fe3O4@ZnO and Fe3O4@SiO2 as Photosensitizer for Targeted Breast Cancer Drug Delivery

Journal of Sciences, Islamic Republic of Iran
مقاله 5، دوره 31، شماره 4، بهمن 2020، صفحه 357-368    اصل مقاله (2.27 M)
نوع مقاله: Original Paper
شناسه دیجیتال (DOI): 10.22059/jsciences.2020.308691.1007559
نویسندگان
ehsan naderi1؛ Mahmoud Naseri2؛ Heidar Taimouri Rad3؛ Reza Zolfaghari Emameh4؛ Gholamreza Farnoosh3؛ Ramezan Ali Taheri* 1
1Nanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Islamic Republic of Iran
2Department of Physics, Malayer University, Malayer, Iran.
3Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Islamic Republic of Iran
4Department of Energy and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), 14965/161, Tehran, Islamic Republic of Iran
چکیده
The present study aimed to prepare Fe3O4 nanocarriers (NCs) by a thermal treatment method. After the Fe3O4 (Fe) NCs was prepared, zinc oxide and silica nanoparticles were added to it as Photosensitizer. The structure, morphology, and magnetic properties of Fe3O4@ZnO (Fe@Zn) and Fe3O4@SiO2 (Fe@Si) NCs were determined by XRD, FT-IR, FESEM, and VSM. Then, the loading and drug release of Fe, Fe@Zn, and Fe@Si NCs were investigated. The curcumin (CUR) release of Fe@Zn+CUR and Fe@Si+CUR increased from 30% and 26% at pH 7.4 to 53% and 57% at pH 5.5, respectively. The cytotoxicity of Fe@Zn and Fe@Si NCs were determined by MTT assay, hemolysis test, acute toxicity, and lethal dose test. The results showed that Fe@Zn and Fe@Si were appropriate for Photodynamic Therapy (PDT) and in the next step, the effect of Fe@Zn, Fe@Si, Fe@Zn+CUR, and Fe@Si+CUR NCs on MCF-7 cells under  visible light were studied. Finally, the ranking of the destruction of cancerous cells of MCF-7 using NCs under  visible light was: Fe@Zn+CUR>Fe@Zn>Fe@Si+CUR>Fe@Si.
کلیدواژه‌ها
Photosensitizer؛ Drug Delivery؛ Curcumin؛ Cytotoxicity؛ Magnetic properties
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