The Potential of 5-aminolevulinic Acid as a Contrast Agent in MR Imaging: Challenges and Opportunities | ||
| Journal of Sciences, Islamic Republic of Iran | ||
| مقاله 2، دوره 32، شماره 1، بهار 2021، صفحه 15-28 اصل مقاله (1.96 M) | ||
| نوع مقاله: Review Articles | ||
| شناسه دیجیتال (DOI): 10.22059/jsciences.2020.310908.1007575 | ||
| نویسندگان | ||
| anita Ebrahimpour1؛ Nader Riahi Alam1؛ Mehdi Khoobi* 2 | ||
| 1Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran. | ||
| 2The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran | ||
| چکیده | ||
| Nowadays, 5-aminolevulinic acid (5-ALA) plays an influential role in the detection of malignant tumors as a photodynamic diagnosis tool. Nevertheless, an outlook regarding 5-ALA applicability in magnetic resonance imaging (MRI) has recently emerged. Many studies confirmed the impact of 5-ALA on promoting intracellular Heme synthesis and iron metabolism, which support the capability of 5-ALA in MRI owing to the susceptibility effect of iron. Therefore, concerning the high safety and high affinity of 5-ALA to tumor cells, 5-ALA-based MRI could be an intriguing method for malignant foci identification. | ||
| کلیدواژهها | ||
| 5-aminolevulinic acid؛ Magnetic resonance imaging؛ Protoporphyrin IX؛ Cellular iron metabolism؛ Transferrin receptor | ||
| مراجع | ||
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آمار تعداد مشاهده مقاله: 865 تعداد دریافت فایل اصل مقاله: 697 |
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