|تعداد مشاهده مقاله||106,238,426|
|تعداد دریافت فایل اصل مقاله||83,138,870|
Preparation of cationized albumin nanoparticles loaded indirubin by high pressure hemogenizer.
|Journal of Computational Applied Mechanics|
|دوره 52، شماره 3، آذر 2021، صفحه 498-506 اصل مقاله (638.84 K)|
|نوع مقاله: Research Paper|
|شناسه دیجیتال (DOI): 10.22059/jcamech.2021.322424.641|
|Houra Nekounam1؛ Rassoul Dinarvand2، 3؛ Rahele Khademi4؛ Fatemeh Asghari1؛ Narges Mahmoodi5؛ Hossein Arzani1؛ Elham Hasanzadeh6؛ Amin Hadi7؛ Roya Karimi8؛ Morteza Kamali1؛ Masood Khosravani* 1|
|1Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran|
|2Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran|
|3Nanotechnology Research Centre, Tehran University of Medical Sciences, Tehran, Iran|
|4International affairs, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran|
|5Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran|
|6Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran|
|7Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran|
|8Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran|
|Indirubin can be applied as an anti-cancer drug for inhibition of brain tumors. However, its performance is reduced due to hydrophobicity. In this study, we synthesized cationic human serum albumin (CHSA) nanoparticle by a new hybrid approach (with chemical and mechanical base) for improvement the surface chemistry of albumin and the amount of indirubin loaded CHSA nanoparticle. In this study, the generated mechanical force from a high-pressure homogenizer (HPH) was used to make nanoparticles with a certain size with narrow polydispersity. The results indicated that the size of indirubin loaded CHSA nanoparticles were 130 nm and their zeta potential were +9. Besides, the encapsulation efficiency and drug loading capacity were found to be 85% and 5.8 %, respectively. To the best to our knowledge, this is the first time that indirubin has been used in albumin nanoparticles. In this study, indirubin loaded CHSA nanoparticles was shown can be a potential candidate for drug delivery in the treatment of glioblastoma. Moreover, the cationized form allows the chemical agent to be transmitted to the brain.|
|Brain Tumor؛ Cationated Human Serum Albumin؛ Indirubin, Glioblastoma؛ Protein Nanoparticles؛ Sustained release|
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