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اثر خطای تعیین ژنوتیپ نشانگر در صحت پیشبینی ارزش اصلاحی ژنومی در صفات آستانهای | ||
علوم دامی ایران | ||
دوره 54، شماره 2، تیر 1402، صفحه 161-173 اصل مقاله (1.7 M) | ||
نوع مقاله: مقاله پژوهشی | ||
شناسه دیجیتال (DOI): 10.22059/ijas.2022.340396.653878 | ||
نویسندگان | ||
میثم لطیفی1؛ یوسف نادری* 2 | ||
1محقق مستقل (دکتری ژنتیک و اصلاح نژاد دام)، دانشکده کشاورزی، گروه علوم دامی، دانشگاه کردستان، کردستان، ایران | ||
2گروه علوم دامی، واحد آستارا، دانشگاه آزاد اسلامی، آستارا، ایران. | ||
چکیده | ||
هدف از این مطالعه بررسی اثر خطای تعیین ژنوتیپ نشانگر و نوع طرح آمیزشی و انتخابی (ارزش اصلاحی و فنوتیپی) در صحت ارزیابی ژنومی تحت سطوح مختلف وراثتپذیری (05/0، 1/0 و 3/0) و تراکم نشانگرها (500، 1000 و 1500) به وسیلهی شبیهسازی در صفت آستانه ای بود. ژنومی شامل دو کروموزوم هر یک به طول 100 سانتی مورگان، و بر روی هر کروموزوم 125 QTL شبیه سازی شد. به منظور شبیهسازی صفت آستانهای، 20 درصد از فنوتیپ برتر در هر نسل دو و مابقی یک در نظر گرفته شدند. ارزش اصلاحی ژنومی با استفاده از اثرات نشانگری برآورد شده توسط روش آماری بیز B پیشبینی شد. صحت ارزیابیهای ژنومی نشان داد که طرح آمیزشی و انتخابی ارزش اصلاحی در مقایسه با طرح آمیزشی و انتخابی فنوتیپی صحت بیشتری دارد. صحت ارزیابیهای ژنومی با افزایش خطای تعیین ژنوتیپ در هر دو طرح آمیزشی و انتخابی ارزش اصلاحی و فنوتیپی کاهش یافت. نتایج نشان داد با افزایش درصد خطای تعیین ژنوتیپ، افزایش تراکم نشانگر منجر به افزایش صحت پیشبینی ارزیابی ژنومی میشود. | ||
کلیدواژهها | ||
طرح آمیزشی و انتخابی؛ وراثتپذیری؛ روش بیز B | ||
عنوان مقاله [English] | ||
Effect of Marker Genotyping Error on the Prediction Accuracy of Genomic Breeding Value in Threshold Traits | ||
نویسندگان [English] | ||
Meysam Latifi1؛ Yousef Naderi2 | ||
1Kurdistan university. Independent researcher (PhD in genetics and Animal Breeding), College of Agriculture, Department of Animal Science, university of Kurdistan, Kurdistan, Iran | ||
2Associate Professor, Department of Animal Science, Astara Branch, Islamic Azad University, Astara, Iran | ||
چکیده [English] | ||
The purpose of this study was to investigate the effect of different rates marker genotyping error and the type of mating and selection design (breeding value and phenotypic) on the accuracy of genomic prediction assessment under different levels of heritability (0.05, 0.1 and 0.3) and marker density (500, 1000 and 1500) by simulation in threshold trait. The genome consisted of two chromosomes, each 100 cM, and 125 QTLs were randomly distributed on each chromosome. In order to simulation a threshold trait, 20 percent of the top-level phenotypes were considered to be 2, and the rest were considered as 1. Genomic breeding value was predicted using marker effects estimated by Bayes B statistical method. Comparison of the accuracy of genomic evaluations showed that selection and mating designs of breeding value was more accurate than the selection and mating designs of phenotypic. The accuracy of genomic prediction decreased with increasing marker genotyping error in both selection and mating designs of breeding value and phenotypic. The results showed that with increasing the percentage of marker genotyping error, increasing the number of markers leads to increasing the accuracy of genomic breeding value prediction. | ||
کلیدواژهها [English] | ||
Selection and mating design, Heritability, Bayes B | ||
مراجع | ||
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