اثر تعاملی شش هفته مکمل دهی بربرین به همراه تمرین هوازی بر برخی از شاخص های اکسایشی و ضداکسایشی و بیان ژن کاسپاز-3 در عضلۀ چهارسرران موش های صحرایی نر دیابتی شده با استرپتوزوسین

1] Anderson J, Couper JJ, Mpundu-Kaambwa C, Giles LC, Gent R, Coppin B, et al. An extra 1,000 steps per day relates to improved cardiovascular health in children with type 1 diabetes. Diabetes Care. 2016;39(8):e108–9. https://doi.org/10.2337/dc16-0526

[2] Vazeou A, Papadopoulou A, Miha M, Drakatos A, Georgacopoulos D. Cardiovascular impairment in children, adolescents, and young adults with type 1 diabetes mellitus (T1DM). Eur J Pediatr. 2008;167:877–84. https://doi.org/10.1007/s00431-007-0603-z

[3] Krause MP, Riddell MC, Hawke TJ. Effects of type 1 diabetes mellitus on skeletal muscle: clinical observations and physiological mechanisms. Pediatr Diabetes. 2011;12(4pt1):345–64. https://doi.org/10.1111/j.1399-5448.2010.00699.x

[4] Mehta MM, Weinberg SE, Chandel NS. Mitochondrial control of immunity: beyond ATP. Nat Rev Immunol. 2017;17(10):608–20. https://www.nature.com/articles/nri.2017.66

 [5] Sifuentes-Franco S, Pacheco-Moisés FP, Rodríguez-Carrizalez AD, Miranda-Díaz AG. The role of oxidative stress, mitochondrial function, and autophagy in diabetic polyneuropathy. J Diabetes Res. 2017;2017. https://doi.org/10.1155/2017/1673081

[6] Scarpulla RC. Nucleus-encoded regulators of mitochondrial function: integration of respiratory chain expression, nutrient sensing and metabolic stress. Biochim Biophys Acta (BBA)-Gene Regul Mech. 2012;1819(9–10):1088–97. https://doi.org/10.1016/j.bbagrm.2011.10.011

[7] Ibuki FK, Bergamaschi CT, da Silva Pedrosa M, Nogueira FN. Effect of vitamin C and E on oxidative stress and antioxidant system in the salivary glands of STZ-induced diabetic rats. Arch Oral Biol. 2020;116:104765. https://doi.org/10.1016/j.archoralbio.2020.104765

[8] Powers SK, Kavazis AN, McClung JM. Oxidative stress and disuse muscle atrophy. J Appl Physiol. 2007;102(6):2389–97. https://doi.org/10.1152/japplphysiol.01202.2006

[9] Sala D, Zorzano A. Differential control of muscle mass in type 1 and type 2 diabetes mellitus. Cell Mol life Sci. 2015;72:3803–17. https://doi.org/10.1007/s00018-015-1954-7

[10] Tang L, Li N, Jian W, Kang Y, Yin B, Sun S, et al. Low-intensity pulsed ultrasound prevents muscle atrophy induced by type 1 diabetes in rats. Skelet Muscle. 2017;7:1–10. https://doi.org/10.1186/s13395-017-0145-7

[11] Perry BD, Caldow MK, Brennan-Speranza TC, Sbaraglia M, Jerums G, Garnham A, et al. Muscle atrophy in patients with Type 2 Diabetes Mellitus: roles of inflammatory pathways, physical activity and exercise. Exerc Immunol Rev. 2016;22:94.

[12] Kannan K, Jain SK. Oxidative stress and apoptosis. Pathophysiology. 2000;7(3):153–63. https://doi.org/10.1016/S0928-4680(00)00053-5

[13] Yu Z, Jia Y, Chen G. Possible involvement of cathepsin B/D and caspase‐3 in deferoxamine‐related neuroprotection of early brain injury after subarachnoid haemorrhage in rats. Neuropathol Appl Neurobiol. 2014;40(3):270–83. https://doi.org/10.1111/nan.12091

[14] McClung JM, Kavazis AN, DeRuisseau KC, Falk DJ, Deering MA, Lee Y, et al. Caspase-3 regulation of diaphragm myonuclear domain during mechanical ventilation–induced atrophy. Am J Respir Crit Care Med. 2007;175(2):150–9. https://doi.org/10.1164/rccm.200601-142OC

[15] Primeau AJ, Adhihetty PJ, Hood DA. Apoptosis in heart and skeletal muscle. Can J Appl Physiol. 2002;27(4):349–95. https://doi.org/10.1139/h02-020

[16] Pal S, Chaki B, Chattopadhyay S, Bandyopadhyay A. High-intensity exercise induced oxidative stress and skeletal muscle damage in postpubertal boys and girls: A comparative study. J strength Cond Res. 2018;32(4):1045–52. https://doi: 10.1519/JSC.0000000000002167

[17] Powers SK, Deminice R, Ozdemir M, Yoshihara T, Bomkamp MP, Hyatt H. Exercise-induced oxidative stress: Friend or foe?. Journal of sport and health science. 2020 Sep 1;9(5):415-25. https://doi.org/10.1016/j.jshs.2020.04.001

[18] Margaritelis NV, Theodorou AA, Paschalis V, Veskoukis AS, Dipla K, Zafeiridis A, Panayiotou G, Vrabas IS, Kyparos A, Nikolaidis MG. Adaptations to endurance training depend on exercise‐induced oxidative stress: exploiting redox interindividual variability. Acta Physiologica. 2018 Feb;222(2):e12898. https://doi.org/10.1111/apha.12898

[19] Feinberg MJ, Lumia AR, McGinnis MY. The effect of anabolic-androgenic steroids on sexual behavior and reproductive tissues in male rats. Physiol Behav. 1997/07/01. 1997;62(1):23–30. https://doi.org/10.1016/S0031-9384(97)00105-4

[20] Møller P, Wallin H, Knudsen LE. Oxidative stress associated with exercise, psychological stress and life-style factors. Chem Biol Interact. 1996;102(1):17–36. https://doi.org/10.1016/0009-2797(96)03729-5

[21] Golbidi S, Badran M, Laher I. Antioxidant and Anti-Inflammatory Effects of Exercise in Diabetic Patients. Exp Diabetes Res. 2012;2012:1–16. https://doi.org/10.1155/2012/941868. [In persian]

[22] Ramezani J, Azarbayjani MA, Peeri M. The Aerobic Training and Berberine Chloride Intervention on Pancreatic Tissue Antioxidant Enzymes and Lipid Peroxidation in Type 1 Diabetic Rats. Iran J diabetes Obes. 2020;11(4):257–64. https://doi.org/10.18502/ijdo.v11i4.2882. [In persian]

[23] Chae CH, Jung SL, An SH, Park BY, Wang SW, Cho IH, et al. RETRACTED: Treadmill exercise improves cognitive function and facilitates nerve growth factor signaling by activating mitogen-activated protein kinase/extracellular signal-regulated kinase1/2 in the streptozotocin-induced diabetic rat hippocampus. Elsevier; 2009. https://doi.org/10.1016/j.neuroscience.2009.09.075

[24] Pan X-R, Li G-W, Hu Y-H, Wang J-X, Yang W-Y, An Z-X, et al. Effects of Diet and Exercise in Preventing NIDDM in People With Impaired Glucose Tolerance: The Da Qing IGT and Diabetes Study. Diabetes Care. 1997 Apr 1;20(4):537 LP – 544. https://doi.org/10.2337/diacare.20.4.537

[25] Yardley JE, Kenny GP, Perkins BA, Riddell MC, Balaa N, Malcolm J, et al. Resistance Versus Aerobic Exercise: Acute effects on glycemia in type 1 diabetes. Diabetes Care [Internet]. 2013 Mar 1;36(3):537–42. https://doi.org/10.2337/dc12-0963

[26] Coskun O, Ocakci A, Bayraktaroglu T, Kanter M. Exercise training prevents and protects streptozotocin-induced oxidative stress and β-cell damage in rat pancreas. Tohoku J Exp Med. 2004;203(3):145–54. https://doi.org/10.1620/tjem.203.145

[27] Yeung AWK, Orhan IE, Aggarwal BB, Battino M, Belwal T, Bishayee A, et al. Berberine, a popular dietary supplement for human and animal health: Quantitative research literature analysis a review. 2020;

[28] Vuddanda PR, Chakraborty S, Singh S. Berberine: a potential phytochemical with multispectrum therapeutic activities. Expert Opin Investig Drugs. 2010;19(10):1297–307. https://doi.org/10.1517/13543784.2010.517745

[29] Thirumalai T, Therasa SV, Elumalai EK, David E. Intense and exhaustive exercise induce oxidative stress in skeletal muscle. Asian Pacific J Trop Dis. 2011;1(1):63–6. https://doi.org/10.1016/S2222-1808(11)60016-9

[30] Alghobashy AA, Alkholy UM, Talat MA, Abdalmonem N, Zaki A, Ahmed IA, et al. Trace elements and oxidative stress in children with type 1 diabetes mellitus. Diabetes, Metab Syndr Obes. 2018;11:85–92. https://doi.org/10.2147/DMSO.S157348

[31] Landers-Ramos RQ, Jenkins NT, Spangenburg EE, Hagberg JM, Prior SJ. Circulating angiogenic and inflammatory cytokine responses to acute aerobic exercise in trained and sedentary young men. Eur J Appl Physiol. 2014;114:1377–84. https://doi.org/10.1007/s00421-014-2861-6

[32] Dede ND, Ipekci S, Kebapcilar L, Arslan M, Kurban S, Yildiz M, et al. Effect of aerobic exercise training on serum malondialdehyde level and quality of life in type 2 diabetes. In: Endocrine Abstracts. Bioscientifica; 2018. https://www.endocrine-abstracts.org/ea/0056/ea0056gp100

[33] Radak Z, Zhao Z, Koltai E, Ohno H, Atalay M. Oxygen consumption and usage during physical exercise: the balance between oxidative stress and ROS-dependent adaptive signaling. Antioxid Redox Signal. 2013;18(10):1208–46. https://doi.org/10.1089/ars.2011.4498

[34] Pereira AS, Spagnol AR, Luciano E, de Almeida Leme JAC. Influência do treinamento físico aeróbio nos marcadores séricos de estresse oxidativo em ratos diabéticos. J Phys Educ. 2016;27(1).

[35] Lima TI, Monteiro IC, Valença S, Leal-Cardoso JH, Fortunato RS, Carvalho DP, et al. Effect of exercise training on liver antioxidant enzymes in STZ-diabetic rats. Life Sci [Internet]. 2015;128:64–71. https://doi.org/10.1016/j.lfs.2015.01.031

[36] Baynes JW, Thorpe SR. The role of oxidative stress in diabetic complications. Curr Opin Endocrinol Diabetes Obes. 1996;3(4):277–84.

[37] Xie X, Chang X, Chen L, Huang K, Huang J, Wang S, et al. Berberine ameliorates experimental diabetes-induced renal inflammation and fibronectin by inhibiting the activation of RhoA/ROCK signaling. Mol Cell Endocrinol. 2013;381(1–2):56–65. https://doi.org/10.1016/j.mce.2013.07.019

[38] Wu D, Wen W, Qi C-L, Zhao R-X, Lü J-H, Zhong C-Y, et al. Ameliorative effect of berberine on renal damage in rats with diabetes induced by high-fat diet and streptozotocin. Phytomedicine. 2012;19(8–9):712–8. https://doi.org/10.1016/j.phymed.2012.03.003

[39] Maritim AC, Sanders aRA, Watkins Iii JB. Diabetes, oxidative stress, and antioxidants: a review. J Biochem Mol Toxicol. 2003;17(1):24–38. https://doi.org/10.1002/jbt.10058

[40] Wang Y, Campbell T, Perry B, Beaurepaire C, Qin L. Hypoglycemic and insulin-sensitizing effects of berberine in high-fat diet-and streptozotocin-induced diabetic rats. Metabolism. 2011;60(2):298–305. https://doi.org/10.1016/j.metabol.2010.02.005

[41] Chatuphonprasert W, Lao-Ong T, Jarukamjorn K. Improvement of superoxide dismutase and catalase in streptozotocin–nicotinamide-induced type 2-diabetes in mice by berberine and glibenclamide. Pharm Biol. 2014;52(4):419–27. https://doi.org/10.3109/13880209.2013.839714

[42] Zhu X, Guo X, Mao G, Gao Z, Wang H, He Q, et al. Hepatoprotection of Berberine Against Hydrogen Peroxide‐induced Apoptosis by Upregulation of Sirtuin 1. Phyther Res. 2013;27(3):417–21. https://doi.org/10.1002/ptr.4728

[43] van der Horst A, Tertoolen LGJ, de Vries-Smits LMM, Frye RA, Medema RH, Burgering BMT. FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2SIRT1. J Biol Chem. 2004;279(28):28873–9. https://doi.org/10.1074/jbc.M401138200

[44] Wang Q, Zhang M, Liang B, Shirwany N, Zhu Y, Zou M-H. Activation of AMP-activated protein kinase is required for berberine-induced reduction of atherosclerosis in mice: the role of uncoupling protein 2. PLoS One. 2011;6(9):e25436. https://doi.org/10.1371/journal.pone.0025436

[45] Gao Y, Ordas R, Klein JD, Price SR. Regulation of caspase-3 activity by insulin in skeletal muscle cells involves both PI3-kinase and MEK-1/2. J Appl Physiol. 2008;105(6):1772–8. https://doi.org/10.1152/japplphysiol.90636.2008

[46] Leeuwenburgh C. Role of apoptosis in sarcopenia. Journals Gerontol Ser A Biol Sci Med Sci. 2003;58(11):M999–1001. https://doi.org/10.1093/gerona/58.11.M999

[47] Phillips T, Leeuwenburgh C. Muscle fiber‐specific apoptosis and TNF‐α signaling in sarcopenia are attenuated by life‐long calorie restriction. FASEB J. 2005;19(6):1–33. https://doi.org/10.1096/fj.04-2870fje

[48] Payne AM, Dodd SL, Leeuwenburgh C. Life-long calorie restriction in Fischer 344 rats attenuates age-related loss in skeletal muscle-specific force and reduces extracellular space. J Appl Physiol. 2003;95(6):2554–62. https://doi.org/10.1152/japplphysiol.00758.2003

[49] Hengartner MO. The biochemistry of apoptosis. Nature. 2000;407(6805):770–6. https://doi.org/10.1038/35037710

[50] Chueh WH, Lin JY. Berberine, an isoquinoline alkaloid, inhibits streptozotocin-induced apoptosis in mouse pancreatic islets through down-regulating Bax/Bcl-2 gene expression ratio. Food Chem [Internet]. 2012;132(1):252–60. https://doi.org/10.1016/j.foodchem.2011.10.065