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Neuroprotective effect of allogeneic biomaterial on rat neocortex after its intramuscular injection | ||
| Iranian Journal of Veterinary Medicine | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 26 اسفند 1402 اصل مقاله (1.46 M) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22059/ijvm.2024.368773.1005479 | ||
| نویسندگان | ||
| Anna Ivanova Lebedeva1؛ Evgeny Musinovich Gareev1؛ Lyalya Akhiyarovna Musina1؛ Alexey Victorovich Prusakov2؛ Anatoliy Vicrorovich Yashin2؛ Vladimir Sergeevich Ponamarev* 2 | ||
| 1Federal State Budgetary Educational Institution of Higher Education “Bashkir State Medical University”, Ministry of Health of the Russian Federation, (All-Russian Center for Eye and Plastic Surgery), | ||
| 2Federal State Budgetary Educational Institution of Higher Education “Saint Petersburg State University of Veterinary Medicine”,Saint Petersburg,Russia, | ||
| چکیده | ||
| Background. Forced physical activity causes a violation of all organs and systems interactions. Allogeneic biomaterial has been used for many years for regeneration, but remote exposure hasn’t been studied. Objectives. The aim of this research is the morphological study of experimental animals' precentral gyrus neocortex under conditions of background forced physical activity and after intramuscular injection of allogeneic biomaterial. Methods. Male Wistar rats were used for the experiment. The Porsolt test, or despair test, was used for 30 days. In the main group (n=10), after all 30 swimming sessions, allogeneic biomaterial (BMA) was injected intramuscularly. In the control group (n=10), the animals were injected with saline in the same volume. 5 and 21 days after the injections, a tolerance load test was performed, after which the animals were taken out of the experiment by insufflation of a lethal dose of chloroform vapors, the brain was removed, and morphological studies were performed. Result. In the experimental group 5 days after the BMA injection, the median level of the multiplicity of tolerant load was significantly higher than in the control group, respectively, and remained so in the long term. The neocortex of the control group animals was characterized by the development of pathomorphological changes. After 21 days, these signs persisted. In the early period after the BMA injection, no signs of nervous tissue edema were detected. A clear architectonics of the neocortex neurocytes layers was preserved. Conclusion. Allogeneic biomaterial has a positive systemic effect on the organism. Also, neuroprotective and immunomodulating effects have been recorded. | ||
| کلیدواژه‌ها | ||
| allogeneic biomaterial؛ cerebral cortex؛ forced swimming؛ neuroprotection؛ rats | ||
| عنوان مقاله [English] | ||
| اثر محافظت عصبی ماده زیستی آلوژنیک بر نئوکورتکس موش پس از تزریق عضلانی آن | ||
| نویسندگان [English] | ||
| آنا ایوانوا لبدوا1؛ یوگنی مویسینوویچ گارو1؛ لیالیا آخیاروونا موسینا1؛ آلکسی ویکتوروویچ پورساکوف2؛ آناتولی ویکتوروویچ یاشین2؛ ولادیمیر سرگیویچ پوناماروف2 | ||
| 1موسسه آموزش عالی بودجه ایالتی فدرال «ایالت باشکر دانشگاه پزشکی، وزارت بهداشت فدراسیون روسیه، (مرکز چشم همه روسیه و جراحی پلاستیک) | ||
| 2موسسه آموزش عالی بودجه ایالتی فدرال "سن پترزبورگ دانشگاه دولتی دامپزشکی، سن پترزبورگ، روسیه | ||
| کلیدواژه‌ها [English] | ||
| مواد زیستی آلوژنیک, قشر مغز, شنای اجباری, محافظت عصبی, موش صحرایی | ||
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آمار تعداد مشاهده مقاله: 87 تعداد دریافت فایل اصل مقاله: 136 |
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