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Assessment of the Toxicity of Polystyrene Microplastic in the Colon and Liver of Adult NMRI Mice | ||
Iranian Journal of Veterinary Medicine | ||
مقاله 17، دوره 19، شماره 2، تیر 2025، صفحه 367-376 اصل مقاله (4.83 M) | ||
نوع مقاله: Original Articles | ||
شناسه دیجیتال (DOI): 10.32598/ijvm.19.2.1005532 | ||
نویسندگان | ||
Somaye Zangene1؛ Hassan Morovvati* 1؛ Hojat Anbara1؛ Nicola Bernabò2 | ||
1Department of Basic Science, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. | ||
2Faculty of Bioscience and Agro-Food and Environmental Technology, University of Teramo, Teramo, Italy. | ||
چکیده | ||
Background: In recent years, microplastics (MPs), emerging environmental contaminants measuring less than 5 mm in diameter, have garnered significant attention. Objectives: This study aims to evaluate the impact of MPs on colon samples, which are directly exposed to MPs that enter the digestive tract through food, and on the liver, which is responsible for processing chemicals from the digestive tract in mice. Methods: During this experiment, 36 adult male mice were randomly divided into four groups of nine animals each. Three groups received polystyrene MPs (PS-MPs) at doses of 0.001, 0.01, and 1 (gavage) for 42 days; a control group was also considered. Tissue samples were collected for histomorphological, histomorphometric, inflammatory factor, and gene expression analyses 24 h after the last treatment. Results: The results showed that receiving PS-MPs negatively affected on the histomorphology and histomorphometry of the colon and liver. Also, PS-MPs caused a significant increase (P<0.05) in inflammatory factors, such as tumor necrosis factor α (TNF-α) and prostaglandin E2 (PGE2), compared to the control group. In addition, a significant increase (P<0.05) in β-catenin and hypoxia-inducible factor 1-alpha (HIF-1α) messenger ribonucleic acid (mRNA) expression was observed in the groups treated with PS-MPs compared to the control group. Conclusion: PS-MPs negatively affect histomorphology and histomorphometry and increase the concentration of TNF-α and PGE2 and the expression of HIF-1α and β-catenin genes in the colon. | ||
کلیدواژهها | ||
Colon؛ Liver؛ Microplastic؛ Inflammation؛ Polystyrene | ||
اصل مقاله | ||
Introduction
Results
References Amran, N. H., Zaid, S. S. M., Mokhtar, M. H., Manaf, L. A., & Othman, S. (2022). Exposure to microplastics during early developmental stage: Review of current evidence. Toxics, 10(10), 597. [DOI:10.3390/toxics10100597] [PMID] Anbara, H., Kian, M., Darya, G. H., & Sheibani, M. T. (2022). Long-term intake of aspartame-induced cardiovascular toxicity is reflected in altered histochemical parameters, evokes oxidative stress, and trigger P53-dependent apoptosis in a mouse model. International Journal of Experimental Pathology, 103(6), 252–262. [DOI:10.1111/iep.12458] [PMID] Anbara, H., Sheibani, M. T., Razi, M., & Kian, M. (2021). Insight into the mechanism of aspartame-induced toxicity in male reproductive system following long-term consumption in mice model. Environmental Toxicology, 36(2), 223–237. [DOI:10.1002/tox.23028] [PMID] Barnes, D. K., Galgani, F., Thompson, R. C., & Barlaz, M. (2009). Accumulation and fragmentation of plastic debris in global environments. Philosophical transactions of the Royal Society of London. Series B, Biological Sciences, 364(1526), 1985–1998.[DOI:10.1098/rstb.2008.0205] [PMID] Bhattacharya, I., Barman, N., Maiti, M., & Sarkar, R. (2019). Assessment of beta-catenin expression by immunohistochemistry in colorectal neoplasms and its role as an additional prognostic marker in colorectal adenocarcinoma. Medicine and Pharmacy Reports, 92(3), 246–252. [DOI:10.15386/mpr-1218] [PMID Burslem, G. M., Kyle, H., Nelson, A., Edwards, T. A., & Wilson, A. J. (2017). Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions. Chemical Science, 8(6), 4188–4202. [DOI:10.1039/c7sc00388a] [PMID] Chen, S., Saeed, A. F. U. H., Liu, Q., Jiang, Q., Xu, H., & Xiao, G. G., et al. (2023). Macrophages in immunoregulation and therapeutics. Signal Transduction and Targeted Therapy, 8(1), 207. [DOI:10.1038/s41392-023-01452-1] [PMID] Chen, Y., Chen, M., & Deng, K. (2023). Blocking the Wnt/β‑catenin signaling pathway to treat colorectal cancer: Strategies to improve current therapies (Review). International Journal of Oncology, 62(2), 24. [DOI:10.3892/ijo.2022.5472] [PMID] Cheng, H., Huang, H., Guo, Z., Chang, Y., & Li, Z. (2021). Role of prostaglandin E2 in tissue repair and regeneration. Theranostics, 11(18), 8836–8854. [DOI:10.7150/thno.63396] [PMID] Chia, W. Y., Ying Tang, D. Y., Khoo, K. S., Kay Lup, A. N., & Chew, K. W. (2020). Nature's fight against plastic pollution: Algae for plastic biodegradation and bioplastics production. Environmental Science and Ecotechnology, 4, [DOI:10.1016/j.ese.2020.100065] [PMID] Chiang J. Y. (2013). Bile acid metabolism and signaling. Comprehensive Physiology, 3(3), 1191–1212. [DOI:10.1002/cphy.c120023] [PMID] Choi, Y. J., Kim, J. E., Lee, S. J., Gong, J. E., Jin, Y. J., & Seo, S., et al. (2021). Inflammatory response in the mid colon of ICR mice treated with polystyrene microplastics for two weeks. Laboratory Animal Research, 37(1), 31. [DOI:10.1186/s42826-021-00109-w] [PMID] Choi, Y. J., Park, J. W., Kim, J. E., Lee, S. J., Gong, J. E., & Jung, Y. S., et al. (2021). Novel characterization of constipation phenotypes in ICR mice orally administrated with polystyrene microplastics. International Journal of Molecular Sciences, 22(11), 5845. [DOI:10.3390/ijms22115845] [PMID] Ghosh, S., Sinha, J. K., Ghosh, S., Vashisth, K., Han, S., & Bhaskar, R. (2023). Microplastics as an emerging threat to the global environment and human health. Sustainability, 15(14), 10821. [DOI:10.3390/su151410821] Guinane, C. M., & Cotter, P. D. (2013). Role of the gut microbiota in health and chronic gastrointestinal disease: Understanding a hidden metabolic organ. Therapeutic Advances in Gastroenterology, 6(4), 295–308. [DOI:10.1177/1756283X13482996] [PMID] Guvenc, M., & Dogan, I. (2024). Effect of Helichrysum plicatum Subs. plicatum on Fructose-induced Nonalcoholıc Fatty Liver. Iranian Journal of Veterinary Medicine, 18(1)(1), 23-32. [Link] Hemarajata, P., & Versalovic, J. (2013). Effects of probiotics on gut microbiota: mechanisms of intestinal immunomodulation and neuromodulation. Therapeutic Advances in Gastroenterology, 6(1), 39–51. [DOI:10.1177/1756283X12459294] [PMID] Hussain AlDulaimi, L. (2024). Effect of oxidative stress on histological and immunohistochemical changes in testes of albino mice. Iranian Journal of Veterinary Medicine, 18(2), 187-194. [DOI:10.32598/IJVM.18.2.1005459] Huang, Z., Weng, Y., Shen, Q., Zhao, Y., & Jin, Y. (2021). Microplastic: A potential threat to human and animal health by interfering with the intestinal barrier function and changing the intestinal microenvironment. The Science of the Total Environment, 785, [PMID] Ilić, I. R., Stojanović, N. M., Radulović, N. S., Živković, V. V., Randjelović, P. J., & Petrović, S., et al. (2019). The Quantitative ER immunohistochemical analysis in breast cancer: Detecting the 3 + 0, 4 + 0, and 5 + 0 Allred Score Cases. Medicina (Kaunas, Lithuania), 55(8), 461. [DOI:10.3390/medicina55080461] [PMID] Jalaudin Basha, N. N., Adzuan Hafiz, N. B., Osman, M. S., & Abu Bakar, N. F. (2023). Unveiling the noxious effect of polystyrene microplastics in aquatic ecosystems and their toxicological behavior on fishes and microalgae. Frontiers in Toxicology, 5, 1135 [DOI:10.3389/ftox.2023.1135081] [PMID] Jang, D. I., Lee, A. H., Shin, H. Y., Song, H. R., Park, J. H., & Kang, T. B., et al. (2021). The role of tumor necrosis factor Alpha (TNF-α) in autoimmune disease and current TNF-α inhibitors in therapeutics. International Journal of Molecular Sciences, 22(5), 2719. [DOI:10.3390/ijms22052719] [PMID] Jin, Y., Lu, L., Tu, W., Luo, T., & Fu, Z. (2019). Impacts of polystyrene microplastic on the gut barrier, microbiota and metabolism of mice. The Science of the Total Environment, 649, 308–317. [DOI:10.1016/j.scitotenv.2018.08.353] [PMID] Jin, Y., Xia, J., Pan, Z., Yang, J., Wang, W., & Fu, Z. (2018). Polystyrene microplastics induce microbiota dysbiosis and inflammation in the gut of adult zebrafish. Environmental Pollution (Barking, Essex : 1987), 235, 322–329. [DOI:10.1016/j.envpol.2017.12.088] [PMID] Johnson, S. E., & Sherding, R. G. (2006). Diseases of the Liver and Biliary Tract. Saunders Manual of Small Animal Practice, 747–809. [DOI:10.1016/B0-72-160422-6/50073-5] [PMCID] Kannan, K., & Vimalkumar, K. (2021). A review of human exposure to microplastics and insights into microplastics as obesogens. Frontiers in Endocrinology, 12, [DOI:10.3389/fendo.2021.724989] [PMID] Kinnebrew, M. A., & Pamer, E. G. (2012). Innate immune signaling in defense against intestinal microbes. Immunological Reviews, 245(1), 113–131. [DOI:10.1111/j.1600-065X.2011.01081.x] [PMID] Liu, M., Liu, J., Xiong, F., Xu, K., Pu, Y., & Huang, J., et al. (2023). Research advances of microplastics and potential health risks of microplastics on terrestrial higher mammals: A bibliometric analysis and literature review. Environmental Geochemistry and Health, 45(6), 2803–2838. [DOI:10.1007/s10653-022-01458-8] [PMID] Mehran, M. A., Monireh, K., Dariush, S., Farinaz, J. A., Reza, T. M., & Shabnam, T., et al. (2023). Apoptosis induction by new coumarin derivatives in a mice model of breast cancer. Archives of Razi Institute, 78(5), 1430–1440. [DOI:10.22092/ARI.2023.78.5.1430] [PMID] Poudineh Morref, M. , Koohi, M. K., Alimolaei, M., Emami, T., & Hassan, J. (2022). A new practical purification method for type d clostridium perfringens epsilon toxin by Size-Exclusion Chromatography (SEC) and Ultrafiltration (UF). Iranian Journal of Veterinary Medicine, 16(2), 178-187. [DOI:10.22059/IJVM.2021.327183.1005185] Parsaeimehr, A., Miller, C. M., & Ozbay, G. (2023). Microplastics and their interactions with microbiota. Heliyon, 9(4), e15104.[DOI:10.1016/j.heliyon.2023.e15104] [PMID] Ren, X., Tang, J., Liu, X., & Liu, Q. (2020). Effects of microplastics on greenhouse gas emissions and the microbial community in fertilized soil. Environmental Pollution (Barking, Essex : 1987), 256, [DOI:10.1016/j.envpol.2019.113347] [PMID] Saeedi, M., (2023). How microplastics interact with food chain: A short overview of fate and impacts. Journal of Food Science and Technology, 61(3), 1–11. Advance online publication. [DOI:10.1007/s13197-023-05720-4] [PMID] Sajjad, M., Huang, Q., Khan, , Khan, M. A., Liu, Y., & Wang, J., et al. (2022). Microplastics in the soil environment: A critical review. Environmental Technology & Innovation, 27, 102408 [DOI:10.1016/j.eti.2022.102408] Sarikoç, F., Kalinli, A., Akgün, H., & Öztürk, F. (2013). An automated prognosis system for estrogen hormone status assessment in breast cancer tissue samples. Turkish Journal of Electrical Engineering and Computer Sciences, 21(4), 1199-1221. [DOI:10.3906/elk-1111-10] Sauerbruch, T., Hennenberg, M., Trebicka, J., & Beuers, U. (2021). Bile Acids, liver cirrhosis, and extrahepatic vascular dysfunction. Frontiers in Physiology, 12, [DOI:10.3389/fphys.2021.718783] [PMID] Singh, S., Sharma, P., Pal, N., Kumawat, M., Shubham, S., Sarma, D. K., & Tiwari, R. R., et (2022). Impact of environmental pollutants on gut microbiome and mental health via the gut-brain Axis. Microorganisms, 10(7), 1457. [DOI:10.3390/microorganisms10071457] [PMID] St-Onge, M., Flamand, N., Biarc, J., Picard, S., Bouchard, L., & Dussault, A., et al. (2007). Characterization of prostaglandin E2 generation through the cyclooxygenase (COX)-2 pathway in human neutrophils. Biochimica et Biophysica Acta, 1771(9), 1235–1245. [DOI:10.1016/j.bbalip.2007.06.002] [PMID] Takiishi, T., Fenero, C. I. M., & Câmara, N. O. S. (2017). Intestinal barrier and gut microbiota: Shaping our immune responses throughout life. Tissue Barriers, 5(4), e1373208. [DOI:10.1080/21688370.2017.1373208] [PMID] Ticho, A. L., Malhotra, P., Dudeja, K., Gill, R. K., & Alrefai, W. A. (2019). Intestinal Absorption of Bile Acids in Health and Disease. Comprehensive Physiology, 10(1), 21–56. [DOI:10.1002/cphy.c190007] [PMID] Tithof, P. K., Roberts, M. P., Guan, W., Elgayyar, M., & Godkin, J. D. (2007). Distinct phospholipase A2 enzymes regulate prostaglandin E2 and F2alpha production by bovine endometrial epithelial cells. Reproductive Biology and Endocrinology: RB&E, 5, [PMID] Vagner, M., Boudry, G., Courcot, L., Vincent, D., Dehaut, A., & Duflos, G., et al. ( 2022). Experimental evidence that polystyrene nanoplastics cross the intestinal barrier of European seabass. Environment International, 166, [DOI:10.1016/j.envint.2022.107340] [PMID] Vajed Ebrahimi, M. T. , Mohammadi Gheshlagh, , & Parham, A. (2024). Using black carrot extracts as an alternative biological dye for tissue staining. Iranian Journal of Veterinary Medicine, 18(2), 279-290. [DOI:10.32598/IJVM.18.2.1005381] Watts, D., Gaete, D., Rodriguez, D., Hoogewijs, D., Rauner,, & Sormendi, S., et al. (2020). Hypoxia Pathway Proteins are Master Regulators of Erythropoiesis. International Journal of Molecular Sciences, 21(21), 8131. [DOI:10.3390/ijms21218131] [PMID] Wen, S., Chen, Y., Tang, Y., Zhao, Y., Liu, S., & You, T., et al. ( 2023). Male reproductive toxicity of polystyrene microplastics: Study on the endoplasmic reticulum stress signaling pathway. Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association, 172, [DOI:10.1016/j.fct.2022.113577] [PMID] Zhao, H., Ming, T., Tang, S., Ren, S., Yang, H., & Liu, M., et al. (2022). Wnt signaling in colorectal cancer: Pathogenic role and therapeutic target. Molecular Cancer, 21(1), 144. [DOI:10.1186/s12943-022-01616-7] [PMID] Zigam, Q. A. , Al-Zubaidy, A. A. , Abbas, W. J., & Al-Mudhafar, R. H. (2023). Cardioprotective effects of octreotide against sepsis-induced cardiotoxicity in mice. Archives of Razi Institute, 78(1), 53-61. [DOI:10.22092/ARI.2022.358339.2201] | ||
مراجع | ||
Amran, N. H., Zaid, S. S. M., Mokhtar, M. H., Manaf, L. A., & Othman, S. (2022). Exposure to microplastics during early developmental stage: Review of current evidence. Toxics, 10(10), 597. [DOI:10.3390/toxics10100597] [PMID]
Anbara, H., Kian, M., Darya, G. H., & Sheibani, M. T. (2022). Long-term intake of aspartame-induced cardiovascular toxicity is reflected in altered histochemical parameters, evokes oxidative stress, and trigger P53-dependent apoptosis in a mouse model. International Journal of Experimental Pathology, 103(6), 252–262. [DOI:10.1111/iep.12458] [PMID]
Anbara, H., Sheibani, M. T., Razi, M., & Kian, M. (2021). Insight into the mechanism of aspartame-induced toxicity in male reproductive system following long-term consumption in mice model. Environmental Toxicology, 36(2), 223–237. [DOI:10.1002/tox.23028] [PMID]
Barnes, D. K., Galgani, F., Thompson, R. C., & Barlaz, M. (2009). Accumulation and fragmentation of plastic debris in global environments. Philosophical transactions of the Royal Society of London. Series B, Biological Sciences, 364(1526), 1985–1998.[DOI:10.1098/rstb.2008.0205] [PMID]
Bhattacharya, I., Barman, N., Maiti, M., & Sarkar, R. (2019). Assessment of beta-catenin expression by immunohistochemistry in colorectal neoplasms and its role as an additional prognostic marker in colorectal adenocarcinoma. Medicine and Pharmacy Reports, 92(3), 246–252. [DOI:10.15386/mpr-1218] [PMID
Burslem, G. M., Kyle, H., Nelson, A., Edwards, T. A., & Wilson, A. J. (2017). Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions. Chemical Science, 8(6), 4188–4202. [DOI:10.1039/c7sc00388a] [PMID]
Chen, S., Saeed, A. F. U. H., Liu, Q., Jiang, Q., Xu, H., & Xiao, G. G., et al. (2023). Macrophages in immunoregulation and therapeutics. Signal Transduction and Targeted Therapy, 8(1), 207. [DOI:10.1038/s41392-023-01452-1] [PMID]
Chen, Y., Chen, M., & Deng, K. (2023). Blocking the Wnt/β‑catenin signaling pathway to treat colorectal cancer: Strategies to improve current therapies (Review). International Journal of Oncology, 62(2), 24. [DOI:10.3892/ijo.2022.5472] [PMID]
Cheng, H., Huang, H., Guo, Z., Chang, Y., & Li, Z. (2021). Role of prostaglandin E2 in tissue repair and regeneration. Theranostics, 11(18), 8836–8854. [DOI:10.7150/thno.63396] [PMID]
Chia, W. Y., Ying Tang, D. Y., Khoo, K. S., Kay Lup, A. N., & Chew, K. W. (2020). Nature's fight against plastic pollution: Algae for plastic biodegradation and bioplastics production. Environmental Science and Ecotechnology, 4, [DOI:10.1016/j.ese.2020.100065] [PMID]
Chiang J. Y. (2013). Bile acid metabolism and signaling. Comprehensive Physiology, 3(3), 1191–1212. [DOI:10.1002/cphy.c120023] [PMID]
Choi, Y. J., Kim, J. E., Lee, S. J., Gong, J. E., Jin, Y. J., & Seo, S., et al. (2021). Inflammatory response in the mid colon of ICR mice treated with polystyrene microplastics for two weeks. Laboratory Animal Research, 37(1), 31. [DOI:10.1186/s42826-021-00109-w] [PMID]
Choi, Y. J., Park, J. W., Kim, J. E., Lee, S. J., Gong, J. E., & Jung, Y. S., et al. (2021). Novel characterization of constipation phenotypes in ICR mice orally administrated with polystyrene microplastics. International Journal of Molecular Sciences, 22(11), 5845. [DOI:10.3390/ijms22115845] [PMID]
Ghosh, S., Sinha, J. K., Ghosh, S., Vashisth, K., Han, S., & Bhaskar, R. (2023). Microplastics as an emerging threat to the global environment and human health. Sustainability, 15(14), 10821. [DOI:10.3390/su151410821]
Guinane, C. M., & Cotter, P. D. (2013). Role of the gut microbiota in health and chronic gastrointestinal disease: Understanding a hidden metabolic organ. Therapeutic Advances in Gastroenterology, 6(4), 295–308. [DOI:10.1177/1756283X13482996] [PMID]
Guvenc, M., & Dogan, I. (2024). Effect of Helichrysum plicatum Subs. plicatum on Fructose-induced Nonalcoholıc Fatty Liver. Iranian Journal of Veterinary Medicine, 18(1)(1), 23-32. [Link]
Hemarajata, P., & Versalovic, J. (2013). Effects of probiotics on gut microbiota: mechanisms of intestinal immunomodulation and neuromodulation. Therapeutic Advances in Gastroenterology, 6(1), 39–51. [DOI:10.1177/1756283X12459294] [PMID]
Hussain AlDulaimi, L. (2024). Effect of oxidative stress on histological and immunohistochemical changes in testes of albino mice. Iranian Journal of Veterinary Medicine, 18(2), 187-194. [DOI:10.32598/IJVM.18.2.1005459]
Huang, Z., Weng, Y., Shen, Q., Zhao, Y., & Jin, Y. (2021). Microplastic: A potential threat to human and animal health by interfering with the intestinal barrier function and changing the intestinal microenvironment. The Science of the Total Environment, 785, [PMID]
Ilić, I. R., Stojanović, N. M., Radulović, N. S., Živković, V. V., Randjelović, P. J., & Petrović, S., et al. (2019). The Quantitative ER immunohistochemical analysis in breast cancer: Detecting the 3 + 0, 4 + 0, and 5 + 0 Allred Score Cases. Medicina (Kaunas, Lithuania), 55(8), 461. [DOI:10.3390/medicina55080461] [PMID]
Jalaudin Basha, N. N., Adzuan Hafiz, N. B., Osman, M. S., & Abu Bakar, N. F. (2023). Unveiling the noxious effect of polystyrene microplastics in aquatic ecosystems and their toxicological behavior on fishes and microalgae. Frontiers in Toxicology, 5, 1135 [DOI:10.3389/ftox.2023.1135081] [PMID]
Jang, D. I., Lee, A. H., Shin, H. Y., Song, H. R., Park, J. H., & Kang, T. B., et al. (2021). The role of tumor necrosis factor Alpha (TNF-α) in autoimmune disease and current TNF-α inhibitors in therapeutics. International Journal of Molecular Sciences, 22(5), 2719. [DOI:10.3390/ijms22052719] [PMID]
Jin, Y., Lu, L., Tu, W., Luo, T., & Fu, Z. (2019). Impacts of polystyrene microplastic on the gut barrier, microbiota and metabolism of mice. The Science of the Total Environment, 649, 308–317. [DOI:10.1016/j.scitotenv.2018.08.353] [PMID]
Jin, Y., Xia, J., Pan, Z., Yang, J., Wang, W., & Fu, Z. (2018). Polystyrene microplastics induce microbiota dysbiosis and inflammation in the gut of adult zebrafish. Environmental Pollution (Barking, Essex : 1987), 235, 322–329. [DOI:10.1016/j.envpol.2017.12.088] [PMID]
Johnson, S. E., & Sherding, R. G. (2006). Diseases of the Liver and Biliary Tract. Saunders Manual of Small Animal Practice, 747–809. [DOI:10.1016/B0-72-160422-6/50073-5] [PMCID]
Kannan, K., & Vimalkumar, K. (2021). A review of human exposure to microplastics and insights into microplastics as obesogens. Frontiers in Endocrinology, 12, [DOI:10.3389/fendo.2021.724989] [PMID]
Kinnebrew, M. A., & Pamer, E. G. (2012). Innate immune signaling in defense against intestinal microbes. Immunological Reviews, 245(1), 113–131. [DOI:10.1111/j.1600-065X.2011.01081.x] [PMID]
Liu, M., Liu, J., Xiong, F., Xu, K., Pu, Y., & Huang, J., et al. (2023). Research advances of microplastics and potential health risks of microplastics on terrestrial higher mammals: A bibliometric analysis and literature review. Environmental Geochemistry and Health, 45(6), 2803–2838. [DOI:10.1007/s10653-022-01458-8] [PMID]
Mehran, M. A., Monireh, K., Dariush, S., Farinaz, J. A., Reza, T. M., & Shabnam, T., et al. (2023). Apoptosis induction by new coumarin derivatives in a mice model of breast cancer. Archives of Razi Institute, 78(5), 1430–1440. [DOI:10.22092/ARI.2023.78.5.1430] [PMID]
Poudineh Morref, M. , Koohi, M. K., Alimolaei, M., Emami, T., & Hassan, J. (2022). A new practical purification method for type d clostridium perfringens epsilon toxin by Size-Exclusion Chromatography (SEC) and Ultrafiltration (UF). Iranian Journal of Veterinary Medicine, 16(2), 178-187. [DOI:10.22059/IJVM.2021.327183.1005185]
Parsaeimehr, A., Miller, C. M., & Ozbay, G. (2023). Microplastics and their interactions with microbiota. Heliyon, 9(4), e15104.[DOI:10.1016/j.heliyon.2023.e15104] [PMID]
Ren, X., Tang, J., Liu, X., & Liu, Q. (2020). Effects of microplastics on greenhouse gas emissions and the microbial community in fertilized soil. Environmental Pollution (Barking, Essex : 1987), 256, [DOI:10.1016/j.envpol.2019.113347] [PMID]
Saeedi, M., (2023). How microplastics interact with food chain: A short overview of fate and impacts. Journal of Food Science and Technology, 61(3), 1–11. Advance online publication. [DOI:10.1007/s13197-023-05720-4] [PMID]
Sajjad, M., Huang, Q., Khan, , Khan, M. A., Liu, Y., & Wang, J., et al. (2022). Microplastics in the soil environment: A critical review. Environmental Technology & Innovation, 27, 102408 [DOI:10.1016/j.eti.2022.102408]
Sarikoç, F., Kalinli, A., Akgün, H., & Öztürk, F. (2013). An automated prognosis system for estrogen hormone status assessment in breast cancer tissue samples. Turkish Journal of Electrical Engineering and Computer Sciences, 21(4), 1199-1221. [DOI:10.3906/elk-1111-10]
Sauerbruch, T., Hennenberg, M., Trebicka, J., & Beuers, U. (2021). Bile Acids, liver cirrhosis, and extrahepatic vascular dysfunction. Frontiers in Physiology, 12, [DOI:10.3389/fphys.2021.718783] [PMID]
Singh, S., Sharma, P., Pal, N., Kumawat, M., Shubham, S., Sarma, D. K., & Tiwari, R. R., et (2022). Impact of environmental pollutants on gut microbiome and mental health via the gut-brain Axis. Microorganisms, 10(7), 1457. [DOI:10.3390/microorganisms10071457] [PMID]
St-Onge, M., Flamand, N., Biarc, J., Picard, S., Bouchard, L., & Dussault, A., et al. (2007). Characterization of prostaglandin E2 generation through the cyclooxygenase (COX)-2 pathway in human neutrophils. Biochimica et Biophysica Acta, 1771(9), 1235–1245. [DOI:10.1016/j.bbalip.2007.06.002] [PMID]
Takiishi, T., Fenero, C. I. M., & Câmara, N. O. S. (2017). Intestinal barrier and gut microbiota: Shaping our immune responses throughout life. Tissue Barriers, 5(4), e1373208. [DOI:10.1080/21688370.2017.1373208] [PMID]
Ticho, A. L., Malhotra, P., Dudeja, K., Gill, R. K., & Alrefai, W. A. (2019). Intestinal Absorption of Bile Acids in Health and Disease. Comprehensive Physiology, 10(1), 21–56. [DOI:10.1002/cphy.c190007] [PMID]
Tithof, P. K., Roberts, M. P., Guan, W., Elgayyar, M., & Godkin, J. D. (2007). Distinct phospholipase A2 enzymes regulate prostaglandin E2 and F2alpha production by bovine endometrial epithelial cells. Reproductive Biology and Endocrinology: RB&E, 5, [PMID]
Vagner, M., Boudry, G., Courcot, L., Vincent, D., Dehaut, A., & Duflos, G., et al. ( 2022). Experimental evidence that polystyrene nanoplastics cross the intestinal barrier of European seabass. Environment International, 166, [DOI:10.1016/j.envint.2022.107340] [PMID]
Vajed Ebrahimi, M. T. , Mohammadi Gheshlagh, , & Parham, A. (2024). Using black carrot extracts as an alternative biological dye for tissue staining. Iranian Journal of Veterinary Medicine, 18(2), 279-290. [DOI:10.32598/IJVM.18.2.1005381]
Watts, D., Gaete, D., Rodriguez, D., Hoogewijs, D., Rauner,, & Sormendi, S., et al. (2020). Hypoxia Pathway Proteins are Master Regulators of Erythropoiesis. International Journal of Molecular Sciences, 21(21), 8131. [DOI:10.3390/ijms21218131] [PMID]
Wen, S., Chen, Y., Tang, Y., Zhao, Y., Liu, S., & You, T., et al. ( 2023). Male reproductive toxicity of polystyrene microplastics: Study on the endoplasmic reticulum stress signaling pathway. Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association, 172, [DOI:10.1016/j.fct.2022.113577] [PMID]
Zhao, H., Ming, T., Tang, S., Ren, S., Yang, H., & Liu, M., et al. (2022). Wnt signaling in colorectal cancer: Pathogenic role and therapeutic target. Molecular Cancer, 21(1), 144. [DOI:10.1186/s12943-022-01616-7] [PMID]
Zigam, Q. A. , Al-Zubaidy, A. A. , Abbas, W. J., & Al-Mudhafar, R. H. (2023). Cardioprotective effects of octreotide against sepsis-induced cardiotoxicity in mice. Archives of Razi Institute, 78(1), 53-61. [DOI:10.22092/ARI.2022.358339.2201] | ||
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