Environmental Monitoring and Human Health Implications of Potentially Toxic Elements in River Water, Akwa Ibom State, Nigeria

Abah, J., Ubwa, S.T., Onyejefu, D.I., & Nomore, S.A. (2013). Assessment of some trace metals content of Oreochromisniloticus obtained from river Okpokwu, Apa Benue State, Nigeria. Res. J. Chem. Sci., 3:70-75. 
Agneta, F.F., Annika, H., Katarina, V., Margareta, W., & Wallen, M. (2006). Assessment factors-applications in health risk assessment of chemicals.     Environ.Res.,104:108 - 127.
Ahmed, J.U., & Goni, M.A. (2010). Heavy metal contamination in water, soil and vegetable of the industrial areas in Dhaka Bangladesh. Environ. Monit. Asses., 166:347-357.
Akan, J.C., Abdulrahman, F.I., Ogugbuaja, V.O., & Reuben, K.D. (2009). Physico-chemical pollutants in Kano Industrial Area, Kano State, Nigeria. J. Appl. Sci. Environ. Sanit., 4 (2): 89-102.
Ayantobo, O.O., Awomeso, J.A., Oluwasanya, G.O., Bada, B.S., & Taiwo A.M. (2014). Non-cancer human health risk assessment from exposure to heavy metals in surface and groundwater in IgunIjesha, Southwest Nigeria. A. J. Environ. Sci., 10 (3): 301-311.
Anyanwu, E.D., & Nwachukwu, E.D. (2020). Heavy metal content and health risk assessment of a South Eastern Nigeria River. Appl. Water Sci., 10 (210) https://doi.org./10.1007/s13201-020-01296-y
Anyanwu, E.D., & Umeham, S.N. (2020). An index approach to heavy metal pollution assessment of Eme River, Umuahia, Nigeria. Sust. Agri., Food Environ. Res., 8, (X):https://doi.org/10.7770/safer-VONO-art2067
Anyanwu, E.D., Adetunji, O.G., & Nwachukwu E.D. (2020). Application of pollution indices and health risk assessment in the heavy metal content of a south-eastern Nigeria river. Pollution, 6 (4): 909-923.
Anyanwu, E.D., Adetunji, O.G., & Nwoke, O.B. (2022). Heavy metal content of water in Ikwu River (Umuahia, Nigeria): pollution indices and health risk assessment approach. Acta Aquat., 18: DOI:10.22392/actaquatr.1060806.
Asaolu, S.S., & Olaofe O. (2004). Biomagnification factors of some heavy and essential metals in sediments, fish and crayfish from Ondo state Coastal Region. Bio. Sci.     Res. Commu., 16:33-39.
ATSDR (2019) ATSDE’S substance priority list (Retrieved 2020 Dec. 25).  ttps://www.atsdr.cdc.gov./spi/indrc. Intmol.
Ayobahan, S.U., Ezenwa, I.M., Orogun E.E., Uriri, J.E., & Wemimo, I.J. (2014). Assessment of Anthropogenic Activities on Water Quality of Benin River. J. Appl. Sci. Environ. Manag., 18 (4): 629-636.
Balakrishnan, A., & Ramu, A. (2016). Evaluation of heavy metal pollution index of groundwater     in and around the coastal area of Guilf of Mannar Biosphere and Palk strait. J. Adv. Chem. Sci., 2 (3): 331-333.
Balali-mood, M., Naseri, K., Tagergorobi, Z., Khazdair, M.R., & Sadeghi. M. (2021). Toxicmechanisms of five heavy metals: mercury, lead, chromium, cadmium and arsenic. Front Pharm.., 12: 1-19. 
Basu, M., Gupta, SK., Singh G., & Mukhopadhyay U. (2011) Multi-Route Risk Assessment from Trihalomethanes in drinking water supplies. Environ. Monit.     Assessm., 178 (1-4): 121-134.
Begum, A., Harikrishna, S., & Khan, I. (2009). Analysis of heavy metals in water, sediments and fish samples of Madivala lakes of Bangalore, Karnataka. Int. J. Chem. Tech. Res., 1 (2), 245–249.
Bouabid, S., Tinakoua, A., Lakhdar-Ghaza, N., & benazzouz, A. (2016). Manganese  neurotoxicity: behavioral disorders associated with dysfunctions in the basal ganglia and neurochemical transmission. J. Neurochem., 136:677 – 691.
Bytyçi, P., Fetoshi, O., Durmishi, B.H., Etemi, F.Z., Cadraku, H., Ismaili, M., & Abazi, A.S. (2018). Status assessment of heavy metals in water of the Lepenci River Basin, Kosova. J. Ecol. Engr., 19 (5): 19-32.
Caylak, K. (2012). Health risk assessment for trace metals, polycyclic aromatic hydrocarbons and trihalomethanes in drinking water of Cankiri, Turkey. E-J. Chem., 9 (4): 1976-1991.https://doi.org/10.1155/2012/172135.
Chen, H., Teng, Y., Lu, S., Wang, Y., & Wang, J. (2015). Contamination features and health risk of soil heavy metals in China. Sci. Total Environ., 512-513 :143-153.
Clancy, H. A., Sun, H., Passantino, L., Kluz, T., Muňoz, A., Zavadil, J., & Costa, M. (2012). Gene expression changes in human lung cells exposed to arsenic, chromium, nickel or vanadium indicate the first steps in cancer. Metallomics, 4 (8): 784-793.
Durmishi, B.H., Abduli, S., Reka, A.A., Ismaili, M., Shabani, A, & Durmishi, A. (2016). Determination of the content of zinc, copper, lead, and cadmium in the River Shkumbini(Pena) with potentiometric stripping analysis. Int. J. Chem. Mat. Sci., 1(1):17-32.
Egbueri, J.C. (2020). Heavy metals pollution sources identification and probabilistic health risk assessment of shallow groundwater in Onitsha, Nigeria. Anal. Lett., 53 (10): 1620-1638.
Ekere, N.R., Ihedioha J.F., Eze, I.S., & Agbazue, VE. (2014). Health risk assessment in relation to heavy metals in water sources in rural regions of south-east Nigeria. Int.  J. Phys. Sci., 9 (6):109-116.
Emurotu, J.E., & Habib, L. O. (2019). Assessment of some water quality of Obuburu River Okene, Kogi State, Nigeria. J. App. Sci. Environ. Manag., 23(11): 1995-2002.
European Union (2002), Heavy metals in wastes. European Commission on Environment.https://ec.europa.eu/environment/waste/studies/pdf/heavymetalsreport.pdf.
Fallahzadeh, R.A., Ghaneian, M.T., Miri, M., & Dashti, M.M. (2017). Spatial analysis and health     risk assessment of heavy metals concentration in drinking water resources. Environ. Sci. Pollut. Res. Int., 24(32): 24790-24802.
Fang, Z., Zhao, M., Zhen, H., Chen, L., Shi, P., & Huang, Z. (2014). Genotoxicity of tri-and hexavalent chromium compounds in Vivo and their modes of action on DNA damage in Vitro. PLoS One, 9: 8:e103194.
FMEnv. (2011). National Environmental (Surface and Groundwater Quality Control) Regulations, S.I. No. 22, Gazette No. 49, Vol. 98 of 24th May, 2011, Federal Ministry of Environment. Abuja, Nigeria.
Ferner, D.J. (2001). Toxicity, heavy metals. Emed. J., 2 (5):1.
Han, B.C., Jeng, W.L., Chen, R.Y., Fang, G.T., Hung, T.C., & Tseng, R.J. (1998). Estimation of target hazard quotients and potential health risks for metals by consumption of seafood in Taiwan. Arch. Environ. Contam. Toxicol., 35: 711-720. 
Hortion, R.K. (1965). An index system for rating water quality. J. Wat. Poll. Cont. Fed., 27(3): 300-315.
Ileperuma, O.A. (2000). Environmental pollution in Sri Lanka: A review. J. Nat. Sci. Found. Sri Laknka, 28 (4) 301-325.
Imneisi, I., & Aydin, M. (2018). Water quality assessment for Elmali stream and Karacomakstream using the comprehensive pollution index in Kastomonu, Turkey. Fresen. Environ. Bull., 27(10): 7031-7038.
Jonah, U.E., Mendie, C.F., & Asuquo, U.G. (2023). Ecological and health risk assessment of trace metals in waters from north-west zone of Akwa Ibom State, Nigeria. Pollution, 9 (1): 271-285.
Jonah, U. E., & Anyanwu, E. D. (2023). Assessment of heavy metal content in ground waters of Ikpe Community, Akwa Ibom State, Niger Delta, Nigeria. Limnol. and Freshwater Biol., 2023 (3): 96-103 .
Jonah, U.E., & Mendie, C.F. (2022). Heavy metals content and health risk assessment of Ikpe Ikot Nkon River, Akwa Ibom State, Nigeria. Food Environ. Safety, XXI (4):345 – 353.
Karmakar, B., Sing, M.K., Choudhary, B.K., Singh, S.K., Egbueri, J.C., Gautam, S.K., &Rawat, K.S. (2021).Investigation of the hydrogeochemistry, groundwater quality, and associated health risks in industrialized regions of Tripura, Northeast India. Environ. Forensics, 22: 1-22.
Koedrith, P., Kim, H. L., Weon, J., & Seo, Y.R. (2013). Toxicogenomic approaches for understanding molecular mechanisms of heavy metal mutagenicity and carcinogenicity.  Int. J. Hyg. Environ. Health, 216 (5): 587-598.
Liu, N., Zhu, Q., Qian, X., Yang, L., Dai, M., Jiang, X., Li, N., Sun, L., Liu, Z., & Lu, G. (2012). Non-carcinogenic risks induced by heavy metals in water from a Chines River. Polish J. Environ. Stud., 21(4): 967-972.
Maigari, A.U., Ekanem, E.O., Garba, I.H., Harami, A., & Akan, J.C. (2016). Health risk assessment for exposure to some selected heavy metals via drinking water from Dadinkowa Dam and River Gombe Abba in Gombe State, Northeast Nigeria. World     J. Analyt. Chem., 4(1):1-5
Matta, G., Naik, P.K., Machell, J., & Kumer, A. (2018). Comparative study on seasonal variation in hydro-chemical parameters of Ganga River water using comprehensive pollution index at Rishikesh, India. Desal. and Water Treat., 118: 87-95. 
Mgbenu, C.N., & Egbueri, J.C. (2019). The hydrogeochemical signatures, quality indices and health risk assessment of water resources in Umunya district, Southeast Nigeria. Appl. Wat. Sci., 9 (1):1-19.
Miapyen, B. S., & Bozkurt, U. (2020). Capital, the State, and Environmental Pollution in Nigeria. SAGE Open, 10 (4). Retrieved August 2022, from https://doi.org/10.1177/2158244020975018. 
Mohan, S.V., Nithila, P., & Reddy, S.J. (1996). Estimation of heavy metals in drinking water and development of heavy metal pollution index. Journal of Environmental Science and Health, Part A: Toxic / Hazardous. Subst. Environ. Engin., 32 (2): 283-289.
Moses, E.A., & Etuk, B.A. (2015). Human health risk assessment of trace metals in water from Qua Iboe River Estuary, Ibeno, Nigeria. J. Environ. Occup.    Sci, 3 (4):150-157. 
Muhammad, S., Shah, M.T., & Khan, S. (2011). Health risk assessment of heavy metals and their source apportionment in drinking water of Kohistan region, Northern Pakistan. Microchem. J., 98: 334-343. 
Naveedullah, N.Z., Chunna, Y., Hui, S.I., Dechao, D., Chaofeng, S., Liping, L., & Yinexu, C. (2014). Concentration and human health risk assessment of selected heavy metals in surface water of the Siling Reservoir Watershed in Zhejing Province, China. Polish J. Environ. Stud., 23(3): 801-811.
Nriagu, J. (2007). Zinc toxicity in human. Available   online:http://www.extranet.elsevier.com/homepage_about/mrwd/norn/zin%20Toxicity%20in%2Humans.pdf.access on 12 April, 2020.
Obasi, R. A, & Madukwe, H. Y.  (2020). Ecological and health risk studies of heavy metals in soils around an abandoned battery factory in Ibadan, South Western Nigeria. Europ. J. Environ. Earth Sci., 1 (4): 1- 8.
Ogwuegbu, M.O.C., & Muhanga, W. (2005). Investigation of lead concentration in the blood of people in the Upperbelt province of Zambia. J. Environ.,1:66-75.
Okonkwo, J.O. & Mothiba, M. (2005). Physico-chemical characteristics and pollution levels of heavy metals in the Rivers in Thohoyandou, South Africa. J. Hydrol., 308: 122-127.
Okon, S.U., Atakpa, E.O., & Ewa-Oboho, I. (2019). Spatial and seasonal characteristics of heavy metals in Ikpa River, Niger Delta, Nigeria. Int. J. Fish. Aquat. Stud., 7 (2): 193-199.
Onyele, O.G., & Anyanwu, E.D. (2018). Human health risk assessment of some heavy metals in a rural spring, Southeastern Nigeria. Afri. J. Environ. Nat. Sci. Res., 1(1): 15-25.
Prasad, B., & Bose, J.M. (2001). Evaluation of heavy metals pollution index for surface and spring water near a limestone mining area of the lower Himalayas. Environ.     Geol., 41:183- 188. 
Rahman, M.S., Molla, A.H., Saha, N.,  & Rahman, A. (2012). Study on heavy metals levels and its     risk assessment in some edible fishes from Bangshi River, Savar, Dhaka, Bangladesh. Food Chem., 134 (4): 1847-1854.
Rovira, J., & Domingo, J.L. (2019). Human health risks due to exposure to inorganic and organic chemicals from textiles: a review. Environ. Res., 68: 62-69.
Salem, H.M., Eweida, EA., & Farag, A. (2000). Heavy metals in drinking water and their environmental impact on human health. ICEHM, pp. 42-556.
Salnikow, K., & Denkhaus, E. (2002). Nickel essentially, toxicity and carcinogenicity, critical review in Oncology/Hematology, 42(1): 35-56.
Satarug, S., Nishijo, M., Ujjin, P., & Moore, MR. (2018). Chronic exposure to low-level cadmium induced zinc-copper deregulation. J. Trace Elem. Med. Biol., 45: 32-38.
SON (2015). Nigerian Standard for Drinking Water Quality. Nigerian Industrial Standard (NIS 554-2015). Standards Organization of Nigeria (SON) Abuja, Nigeria.
USEPA (1990). Guidance for Performing Aggregate Exposure and Risk Assessments. Office of Pesticide Programs. United State Environmental Protection Agency. Washington DC, USA.
USEPA IRIS (2011). US Environmental Protection Agency’s Integrated Risk Information System; Environmental Protection Agency Region 1. United States Environmental Protection Agency. Washington dc, USA.
Xiao, X., Zhang, J., Wang, H., Han, X., Ma, J., Ma, Y. , & Luan, H. (2020). Distribution and health     risk assessment of potentially toxic elements in soil around coal industrial areas: a global meta- analysis. Sci. Total Environ, 713: 135-292.
Young, R.A. (2005). Toxicity Profiles: Toxicity summary for cadmium, risk assessment information system, RAIS, University of Tennessee (raise.ornl.gov/tox/profiles/cadmium.shtml)
Zhang, W., Aschner, M., & Ghers-Egea, J. (2003). Brain barrier system: a new frontier in metal Neurotoxicological Research. Toxicol. Appl. Pharmacol., 192 (1):1-11.