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Superparamagnetic 3-mercaptopropionic acid capped FePt nanoparticles as delivery carriers of curcumin and their preferential cytotoxic effect on MDA-MB-231 breast cancer cells | ||
| Journal of Food and Bioprocess Engineering | ||
| مقاله 1، دوره 6، شماره 2، بهمن 2023، صفحه 1-7 اصل مقاله (1.8 M) | ||
| نوع مقاله: Original research | ||
| شناسه دیجیتال (DOI): 10.22059/jfabe.2023.368315.1157 | ||
| نویسندگان | ||
| Seyed-Behnam Ghaffari؛ Mohammad-Hossein Sarrafzadeh* | ||
| School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran. | ||
| چکیده | ||
| In this study, functionalized superparamagnetic FePt nanoparticles (NPs) as carriers for targeted delivery of curcumin (CUR) to tumors were developed. FePt NPs were synthesized via the co-reduction of metal salts in the presence of 3-mercaptopropionic acid (MPA) to form water-dispersible carboxyl-terminated superparamagnetic NPs. CUR molecules were then conjugated to the particles through the activation of the carboxyl functional groups by 1,1′-carbonyldiimidazole (CDI) and the formation of ester bonds. XRD, FTIR, TEM, DLS, EDS and VSM were performed to evaluate the structure and properties of the particles. As-synthesized CUR-conjugated FePt NPs (CUR-FePt) were spherical core-shell structured particles with an average size of 17 nm, and the particles showed superparamagnetic properties even after the CUR conjugation. The in-vitro release results indicated relatively high CUR conjugation stability, and only 22% of CUR molecules were released after a 16 h period. MTT cytotoxicity evaluations showed that the conjugation of CUR to the surface of the particles did not alert the anticancer activity of CUR against MDA-MB-231 breast cancer cell lines. Moreover, no cytotoxic activity was observed against HEK293 normal cells. The results qualify the as-synthesized functionalized FePt NPs as potent candidates for magnetically guided drug delivery for cancer treatment. | ||
| کلیدواژهها | ||
| Magnetic nanomaterials؛ Targeted drug delivery؛ Iron-platinum؛ Cancer treatment؛ Curcumin | ||
| مراجع | ||
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